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Titolo:
Morphine induces synchronous oscillatory discharges in the rat locus coeruleus
Autore:
Zhu, H; Zhou, W;
Indirizzi:
Univ Mississippi, Med Ctr, Dept Pharmacol & Toxicol, Jackson, MS 39216 USAUniv Mississippi Jackson MS USA 39216 ol & Toxicol, Jackson, MS 39216 USA Univ Mississippi, Med Ctr, Dept Surg Otolaryngol Neurol & Anat, Jackson, MS 39216 USA Univ Mississippi Jackson MS USA 39216 eurol & Anat, Jackson, MS 39216 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 21, volume: 21, anno: 2001,
pagine: NIL_7 - NIL_11
SICI:
0270-6474(20011101)21:21<NIL_7:MISODI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; DENTATE GYRUS; CERULEUS NEURONS; NITRIC-OXIDE; LATE-PHASE; DEPENDENCE; TOLERANCE; NOREPINEPHRINE; INHIBITION; MODULATION;
Keywords:
locus coeruleus; morphine; synchronous oscillation; multiple-electrode recording; noradrenaline; synaptic plasticity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Zhu, H Univ Mississippi, Med Ctr, Dept Pharmacol & Toxicol, 2500 N State St, Jackson, MS 39216 USA Univ Mississippi 2500 N State St Jackson MS USA 39216 MS 39216 USA
Citazione:
H. Zhu e W. Zhou, "Morphine induces synchronous oscillatory discharges in the rat locus coeruleus", J NEUROSC, 21(21), 2001, pp. NIL_7-NIL_11

Abstract

The noradrenergic locus coeruleus (LC) plays a role in opioid dependence and withdrawal. In the present study, using a multiple-electrode recording technique that allowed several LC neurons to be recorded simultaneously overlong time periods, LC neuronal activities were recorded before and after intracerebroventricular injection of morphine (26 nmol) under halothane anesthesia. We found that morphine did not simply decrease firing rates of LC neurons, as reported in earlier studies, but that it induced persistent oscillatory discharges in 49% (87 of 178) of the LC neurons recorded. Cross-correlation analysis revealed that almost all LC neurons (86 of 87) that exhibited oscillatory discharges were synchronized with at least one other neuron. When stated in terms of simultaneously recorded neuron pairs, 59% (292 of 492) of the oscillatory neuron pairs discharged synchronously. The morphine-induced synchronous oscillation began at similar to 10 min after morphine injection, reached its peak in similar to 20-30 min, persisted throughoutthe recording periods (up to 110 min after morphine injection, the longestrecording time), and were reversed by an opioid receptor antagonist naltrexone. These data suggest that although the overall firing rate of LC neurons was reduced by morphine, the morphine- induced synchronous oscillatory activity may summate temporally and spatially at LC axon terminals and facilitate release of noradrenaline. Noradrenaline is an important neuromodulatorand has been shown to induce and facilitate synaptic plasticity at LC target sites. We propose that the morphine-induced long-lasting synchronous oscillatory activity in the LC may be a neuronal signal that could induce synaptic plasticity leading to opioid addiction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:22:59