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Titolo:
Myocytes respond in vivo to an antibody reactive with the acetylcholine receptor by upregulating interleukin-15: an interferon-gamma activator with the potential to influence the severity and course of experimental myasthenia gravis.
Autore:
Stegall, T; Krolick, KA;
Indirizzi:
Univ Texas, Hlth Sci Ctr, Dept Microbiol, San Antonio, TX 78229 USA Univ Texas San Antonio TX USA 78229 Microbiol, San Antonio, TX 78229 USA
Titolo Testata:
JOURNAL OF NEUROIMMUNOLOGY
fascicolo: 2, volume: 119, anno: 2001,
pagine: 377 - 386
SICI:
0165-5728(20011001)119:2<377:MRIVTA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
IFN-GAMMA; HUMAN MYOBLASTS; ADHESION MOLECULES; LEWIS RATS; EXPRESSION; DISEASE; MUSCLE; CELLS; MICE; RESPONSIVENESS;
Keywords:
IFN-gamma; IL-4; IL-15; experimental myasthenia gravis; muscle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Krolick, KA Univ Texas, Hlth Sci Ctr, Dept Microbiol, 7703 Floyd Curl Dr,Mail Code 7758, San Antonio, TX 78229 USA Univ Texas 7703 Floyd Curl Dr,MailCode 7758 San Antonio TX USA 78229
Citazione:
T. Stegall e K.A. Krolick, "Myocytes respond in vivo to an antibody reactive with the acetylcholine receptor by upregulating interleukin-15: an interferon-gamma activator with the potential to influence the severity and course of experimental myasthenia gravis.", J NEUROIMM, 119(2), 2001, pp. 377-386

Abstract

The monoclonal antibody, mAb35, which binds the main immunogenic region ofthe post-junctional muscle receptor for acetylcholine (AM), results in contractile dysfunction and symptoms of experimental myasthenia gravis (EAMG). As described below, exposure to mAb35 also results in the production by muscle of increased levels of the interferon-gamma (IFN-gamma)-activating cytokine, interleukin-15. This effect is accompanied by the increased trafficking of leukocytes through muscle, some that produce IFN-gamma. These observations may be relevant to the induction of disease symptoms since numerous reports from other investigators indicate that IFN-gamma may play a pivotalrole in this disease process. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 16:03:29