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Titolo:
Increased intrathecal production of apolipoprotein D in multiple sclerosis
Autore:
Reindl, M; Knipping, G; Wicher, I; Dilitz, E; Egg, R; Deisenhammer, F; Berger, T;
Indirizzi:
Innsbruck Univ, Dept Neurol, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 eurol, A-6020 Innsbruck, Austria Graz Univ, Dept Med Biochem & Mol Biol, A-8010 Graz, Austria Graz Univ Graz Austria A-8010 d Biochem & Mol Biol, A-8010 Graz, Austria
Titolo Testata:
JOURNAL OF NEUROIMMUNOLOGY
fascicolo: 2, volume: 119, anno: 2001,
pagine: 327 - 332
SICI:
0165-5728(20011001)119:2<327:IIPOAD>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROLOGICAL DISORDERS; INCREASED EXPRESSION; TISSUE DISTRIBUTION; PERIPHERAL-NERVE; RAT HIPPOCAMPUS; MESSENGER-RNA; IGG ANALYSES; IDENTIFICATION; PRINCIPLES; ALBUMIN;
Keywords:
apolipoprotein D (apoD); multiple sclerosis (MS); neurological diseases; lipid metabolism; disease progression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Berger, T Innsbruck Univ, Dept Neurol, Anichstr 35, A-6020 Innsbruck, Austria Innsbruck Univ Anichstr 35 Innsbruck Austria A-6020 ck, Austria
Citazione:
M. Reindl et al., "Increased intrathecal production of apolipoprotein D in multiple sclerosis", J NEUROIMM, 119(2), 2001, pp. 327-332

Abstract

Apolipoprotein D (apoD) is a small glycoprotein responsible for the local transport of small hydrophobic ligands. Within the nervous system, apoD maybe an acute phase protein that is upregulated in a variety of neuropathological conditions and is involved in the removal of lipids during nerve celldegeneration and provision of lipids during the regenerative phase. In this study, we measured cerebrospinal fluid (CSF) and serum apoD levelsin patients with multiple sclerosis (MS), chronic inflammatory demyelinating polyneuropathy (CIDP), Guillain-Barre Syndrome (GBS), infectious inflammatory neurological diseases (INID) and non-inflammatory neurological diseases (NND). We found that mean CSF apol) levels are significantly increased in patients with CIDP/GBS reflecting an acute blood-nerve barrier leakage. In contrast, MS is characterized by an increased intrathecal apoD release asmeasured by the apoD index. Thus, the results of our study provide the first evidence of an increased intrathecal production of apoD in MS. Moreover,we demonstrate that mean apoD indices are highest in MS patients at the time of their first clinical exacerbation. CSF apoD levels and apoD indices correlate with MS disease duration but not with disability or age. Finally, we found that corticosteroid treatment resulted in significantly elevated CSF apoD levels. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:07:46