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Titolo:
Polygenic control of autoimmune peripheral nerve inflammation in rat
Autore:
Dahlman, I; Wallstrom, E; Jiao, H; Luthman, H; Olsson, T; Weissert, R;
Indirizzi:
Karolinska Hosp, Ctr Mol Med, Neuroimmunol Unit, S-17176 Stockholm, SwedenKarolinska Hosp Stockholm Sweden S-17176 Unit, S-17176 Stockholm, Sweden Karolinska Hosp, Ctr Mol Med, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 Med, S-17176 Stockholm, Sweden Karolinska Inst, Dept Mol Med, S-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17176 Med, S-17176 Stockholm, Sweden Univ Tubingen, Dept Neurol, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 Neurol, D-72076 Tubingen, Germany
Titolo Testata:
JOURNAL OF NEUROIMMUNOLOGY
fascicolo: 2, volume: 119, anno: 2001,
pagine: 166 - 174
SICI:
0165-5728(20011001)119:2<166:PCOAPN>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUILLAIN-BARRE-SYNDROME; EXPERIMENTAL ALLERGIC NEURITIS; OIL-INDUCED ARTHRITIS; CAMPYLOBACTER-JEJUNI; RHEUMATOID-ARTHRITIS; ANTI-GM1 ANTIBODIES; SUSCEPTIBILITY LOCI; MULTIPLE-SCLEROSIS; LINKAGE ANALYSIS; LEWIS RAT;
Keywords:
autoimmunity; gene; in vivo animal models; immunoglobulin; Th1/Th2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Weissert, R Karolinska Hosp, Ctr Mol Med, Neuroimmunol Unit, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 6 Stockholm, Sweden
Citazione:
I. Dahlman et al., "Polygenic control of autoimmune peripheral nerve inflammation in rat", J NEUROIMM, 119(2), 2001, pp. 166-174

Abstract

Experimental autoimmune neuritis (EAN) is the principal animal model for Guillain-Barre syndrome (GBS), an inflammatory disease of the peripheral nervous system. Little is known on the genetic regulation of these diseases. We provide the first genetic linkage analysis of EAN. Susceptibility to EAN in a rat F2 population segregated with high levels of anti-PNM IgG, as wellas IgG2b and IgG2c isotype levels, which support that disease genes regulate preferential Th1/Th2 differentiation. Linkage analysis demonstrated co-localization of EAN loci with reported susceptibility loci for experimental arthritis and/or encephalomyelitis and a new region on chromosome 17, Further dissection of these loci may disclose disease pathways in GBS. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 07:07:18