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Titolo:
Brain iron pathways and their relevance to Parkinson's disease
Autore:
Berg, D; Gerlach, M; Youdim, MBH; Double, KL; Zecca, L; Riederer, P; Becker, G;
Indirizzi:
Univ Wurzburg, Dept Neurol, D-8700 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-8700 t Neurol, D-8700 Wurzburg, Germany Univ Wurzburg, Dept Child & Youth Psychiat, D-8700 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-8700 Psychiat, D-8700 Wurzburg, Germany Univ Wurzburg, Dept Psychiat & Psychotherapy, D-8700 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-8700 otherapy, D-8700 Wurzburg, Germany Technion Israel Inst Technol, Dept Pharmacol, Haifa, Israel Technion Israel Inst Technol Haifa Israel Dept Pharmacol, Haifa, Israel Prince Wales Med Res Inst, Sydney, NSW, Australia Prince Wales Med Res Inst Sydney NSW Australia t, Sydney, NSW, Australia Natl Fdn, Ctr Excellence Parkinsons Dis, Miami, FL USA Natl Fdn Miami FL USA Fdn, Ctr Excellence Parkinsons Dis, Miami, FL USA Univ Saarland, Dept Neurol, Hamburg, Germany Univ Saarland Hamburg Germany v Saarland, Dept Neurol, Hamburg, Germany
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 2, volume: 79, anno: 2001,
pagine: 225 - 236
SICI:
0022-3042(200110)79:2<225:BIPATR>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN SUBSTANTIA-NIGRA; TRANSFERRIN RECEPTOR; HEREDITARY HEMOCHROMATOSIS; HEME OXYGENASE-1; ALPHA-SYNUCLEIN; BASAL GANGLIA; MESSENGER-RNA; CELLULAR-DISTRIBUTION; CEREBROSPINAL-FLUID; OXIDATIVE STRESS;
Keywords:
auto-oxidation; iron metabolism; oxidative stress; Parkinson's disease; alpha-synuclein aggregation; transcranial ultrasound;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
175
Recensione:
Indirizzi per estratti:
Indirizzo: Berg, D Univ Wurzburg, Dept Neurol, Josef Schneider Str 11, D-8700 Wurzburg, Germany Univ Wurzburg Josef Schneider Str 11 Wurzburg Germany D-8700 many
Citazione:
D. Berg et al., "Brain iron pathways and their relevance to Parkinson's disease", J NEUROCHEM, 79(2), 2001, pp. 225-236

Abstract

A central role of iron in the pathogenesis of Parkinson's disease (PD), due to its increase in substantia nigra pars compacta dopaminergic neurons and reactive microglia and its capacity to enhance production of toxic reactive oxygen radicals, has been discussed for many years. Recent transcranial ultrasound findings and the observation of the ability of iron to induce aggregation and toxicity of alpha -synuclein have reinforced the critical role of iron in the pathogenesis of nigrostriatal injury. Presently the mechanisms involved in the disturbances of iron metabolism in PD remain obscure. In this review we summarize evidence from recent studies suggesting disturbances of iron metabolism in PD at possibly different levels including iron uptake, storage, intracellular metabolism, release and post-transcriptionalcontrol. Moreover we outline that the interaction of iron with other molecules, especially a-synuclein, may contribute to the process of neurodegeneration. Because many neurodegenerative diseases show increased accumulation of iron at the site of neurodegeneration, it is believed that maintenance of cellular iron homeostasis is crucial for the viability of neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 13:18:21