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Titolo:
Presumed common source outbreaks of hepatitis A in an endemic area confirmed by limited sequencing within the VP1 region
Autore:
Arauz-Ruiz, P; Sundqvist, L; Garcia, Z; Taylor, L; Visona, K; Norder, H; Magnius, LO;
Indirizzi:
Swedish Inst Infect Dis Control, Dept Virol, S-17182 Stockholm, Sweden Swedish Inst Infect Dis Control Stockholm Sweden S-17182 ockholm, Sweden Louisiana State Univ, Int Ctr Med Res & Training, San Jose, Costa Rica Louisiana State Univ San Jose Costa Rica Training, San Jose, Costa Rica
Titolo Testata:
JOURNAL OF MEDICAL VIROLOGY
fascicolo: 3, volume: 65, anno: 2001,
pagine: 449 - 456
SICI:
0146-6615(200111)65:3<449:PCSOOH>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLETE NUCLEOTIDE-SEQUENCE; POLYMERASE CHAIN-REACTION; A VIRUS HAV; MOLECULAR EPIDEMIOLOGY; MONOCLONAL-ANTIBODIES; GENETIC RELATEDNESS; CELL-CULTURE; STRAINS; INFECTION; HEMOPHILIA;
Keywords:
molecular epidemiology; hepatitis A; Central America; genotypes; viremia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Magnius, LO Swedish Inst Infect Dis Control, Dept Virol, S-17182 Stockholm, Sweden Swedish Inst Infect Dis Control Stockholm Sweden S-17182 den
Citazione:
P. Arauz-Ruiz et al., "Presumed common source outbreaks of hepatitis A in an endemic area confirmed by limited sequencing within the VP1 region", J MED VIROL, 65(3), 2001, pp. 449-456

Abstract

Hepatitis A virus isolates from anti-HAV IgM positive sera of 70 hepatitiscases in two outbreaks and 216 other cases in Central America, 136 sporadic cases and 53 cases from an hyperendemic region in Costa Rica, were compared by phylogenetic analyses within the VP1 region. The outbreaks in all 531cases, in 1992 and 1999, respectively, were presumed water borne. In the first outbreak, HAV RNA could be detected in 70% of the cases sampled during6 weeks after onset of jaundice. In the hyper-endemic region of San Ramon in Costa Rica, 1,932 cases were registered between 1972 and 1985. All isolates belonged to subtype 1A. Background isolates from Costa Rica and El Salvador tended to form separate subclusters in the phylogenetic tree construction and were mostly unrelated to subtype 1A strains from other parts of theworld. Based on their amino acid sequences, four HAV strains, all related to CR326 sampled in Costa Rica in 1960, were found to have circulated in the area during the last three decades. However, on the basis of nucleotide variability the isolates from the outbreaks could be distinguished from the strains from sporadic cases and sequence analysis could confirm the epidemiological homogeneity of both outbreaks. In the hyper-endemic region, 16 different sequences were encountered forming one single subcluster. Thus, limited sequencing within the VP1 region proved useful to identify outbreaks ofhepatitis A in a highly endemic area, where most strains were local and only one subtype was prevalent. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 17:23:50