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Titolo:
Bleeding diathesis in multiple myeloma
Autore:
Saif, MW; Allegra, CJ; Greenberg, B;
Indirizzi:
Wallace Tumor Inst, UAB Div Hematol Oncol, Birmingham, AL 35294 USA Wallace Tumor Inst Birmingham AL USA 35294 ncol, Birmingham, AL 35294 USA NCI, NIH, Bethesda, MD 20889 USA NCI Bethesda MD USA 20889NCI, NIH, Bethesda, MD 20889 USA Chester Cty Hematol Oncol Serv, W Chester, PA 19380 USA Chester Cty Hematol Oncol Serv W Chester PA USA 19380 ester, PA 19380 USA
Titolo Testata:
JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH
fascicolo: 5, volume: 10, anno: 2001,
pagine: 657 - 660
SICI:
1525-8165(200110)10:5<657:BDIMM>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISORDER; INHIBITOR; PATIENT; ANTICOAGULANT; AMYLOIDOSIS; DEFICIENCY; THROMBIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Saif, MW Wallace Tumor Inst, UAB Div Hematol Oncol, Room 262-A,1824 6th Ave S, Birmingham, AL 35294 USA Wallace Tumor Inst Room 262-A,1824 6th Ave S Birmingham AL USA 35294
Citazione:
M.W. Saif et al., "Bleeding diathesis in multiple myeloma", J HEMATH ST, 10(5), 2001, pp. 657-660

Abstract

Patients with multiple myeloma having a higher titer of serum paraproteinscan manifest hemostatic abnormalities. Most of these abnormalities predispose the patient to hemorrhage. Less commonly, thrombotic complications may occur in association with paraprotein disorders. We investigated a 56-year-old female diagnosed with multiple myeloma (type IgG kappa, 59 g/L) whose coagulation profile showed an increase in thrombin time and prothrombin time. To investigate the etiology of the abnormal coagulopathy, further diagnostic studies including coagulation factor assays, platelet aggregation studies, replitase time, mixing studies using pooled normal plasma, and protamine were performed. Mixing studies demonstrated correction of the prothrombintime. Thrombin time was near-corrected but the replitase-time was not corrected by these mixing studies. After chemotherapy, the paraprotein concentration decreased (12g/L) and the coagulation results returned to normal. Patients with multiple myeloma may develop bleeding diathesis secondary to a variety of mechanisms. One such mechanism is direct inhibition of fibrin monomer aggregation due to the paraprotein, resulting in prolongation of the thrombin time and the replitase time. The failure to correct the former by the addition of protamine further augments the direct role of FAB portion ofthe paraprotein molecule on inhibition of fibrin monomers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 03:02:38