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Titolo:
Genetic differences in CYP2C19 single nucleotide polymorphisms among four Asian populations
Autore:
Yamada, S; Onda, M; Kato, S; Matsuda, N; Matsuhisa, T; Yamada, N; Miki, M; Matsukura, N;
Indirizzi:
Nippon Med Coll, Dept Surg 1, Bunkyo Ku, Tokyo 1138603, Japan Nippon Med Coll Tokyo Japan 1138603 g 1, Bunkyo Ku, Tokyo 1138603, Japan
Titolo Testata:
JOURNAL OF GASTROENTEROLOGY
fascicolo: 10, volume: 36, anno: 2001,
pagine: 669 - 672
SICI:
0944-1174(200110)36:10<669:GDICSN>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
S-MEPHENYTOIN 4'-HYDROXYLATION; JAPANESE POPULATION; OMEPRAZOLE METABOLISM; POOR METABOLIZERS; LANSOPRAZOLE; PHARMACOKINETICS; PHENOTYPE; IDENTIFICATION; HYDROXYLATION; FREQUENCIES;
Keywords:
CYP2C19; single nucleotide polymorphisms; Helicobacter pylori; proton pump inhibitor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Matsukura, N Nippon Med Coll, Dept Surg 1, Bunkyo Ku, 1-1-5 Sendagi, Tokyo1138603, Japan Nippon Med Coll 1-1-5 Sendagi Tokyo Japan 1138603 603, Japan
Citazione:
S. Yamada et al., "Genetic differences in CYP2C19 single nucleotide polymorphisms among four Asian populations", J GASTRO, 36(10), 2001, pp. 669-672

Abstract

Background This study was designed to compare genetic differences in single-nucleotide polymorphisms of the S-mephenytoin 4'-hydroxylation (CYP2C19) gene among four Asian populations. Methods. Polymerase chain reaction with restriction fragment length polymorphism (PCR-RFLP) analysis of CYP2C19 wasconducted in Japanese, Chinese, Thai, and Vietnamese populations. All genotype frequencies were analyzed. Wild-type homozygote and wild-type heterozygote genotypes were extensive proton pump inhibitor (PPI) metabolizers. Mutant-type heterozygote and mutant-type homozygote genotypes were poor PPI metabolizers. Results. No significant differences in CYP2C19 phenotype, calculated based on genotype frequencies, (P > 0.05) were found among the four populations. Conclusions. Many factors, including CYP2C19 polymorphisms, affect the success rate of Helicobacter pylori eradication with PPI-based therapy. We suspect that CYP2C19 polymorphisms may not be the main factor associated with differences among these four Asian populations in the success rates of H. pylori eradication with PPI-based therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/10/20 alle ore 11:12:19