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Titolo:
Plasmapheresis in the treatment of an acute pancreatitis due to protease inhibitor-induced hypertriglyceridemia
Autore:
Routy, JP; Smith, GHR; Blank, DW; Gilfix, BM;
Indirizzi:
McGill Univ, Ctr Hlth, Div Hematol, Montreal, PQ, Canada McGill Univ Montreal PQ Canada r Hlth, Div Hematol, Montreal, PQ, Canada McGill Univ, Ctr Hlth, Immunodeficiency Serv, Montreal, PQ, Canada McGill Univ Montreal PQ Canada munodeficiency Serv, Montreal, PQ, Canada McGill Univ, Ctr Hlth, Dept Med, Div Clin Biochem, Montreal, PQ, Canada McGill Univ Montreal PQ Canada d, Div Clin Biochem, Montreal, PQ, Canada
Titolo Testata:
JOURNAL OF CLINICAL APHERESIS
fascicolo: 3, volume: 16, anno: 2001,
pagine: 157 - 159
SICI:
0733-2459(2001)16:3<157:PITTOA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
RITONAVIR THERAPY; HYPERLIPIDEMIA;
Keywords:
plasmapheresis; HIV; ritonavir; hypertriglyceridemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Gilfix, BM Royal Victoria Hosp, 687 Pine Ave W, Montreal, PQ H3A 1A1, Canada Royal Victoria Hosp 687 Pine Ave W Montreal PQ Canada H3A 1A1 a
Citazione:
J.P. Routy et al., "Plasmapheresis in the treatment of an acute pancreatitis due to protease inhibitor-induced hypertriglyceridemia", J CLIN APH, 16(3), 2001, pp. 157-159

Abstract

The use of protease inhibitors such as ritonavir to treat HIV-infected individuals has been associated with lipodystrophy, combined hyperlipidemias, and hypertriglyceridemia-induced pancreatitis. We report hereon the treatment by plasmapheresis of a HIV-patient who presented with a rapid onset of severe ritonavir-induced hypertriglyceridemia complicated with an acute pancreatitis. A 35-year-old HIV-1 positive male following 3 weeks of ritonavir treatment presented with nausea, abdominal pain, a distended abdomen, and the following laboratory values: amylase (238 U/L), lipase (864 U/L), total cholesterol (27.1 mmol/L), and triglycerides (62.9 mmol/L). Following two plasmaphereses, the levels of total cholesterol, triglycerides, lipase, and amylase declined drastically and the patient was discharged home after 4 days with lipid and pancreatic enzyme levels within the reference range. To our knowledge, this is the first case of pancreatitis due to a PI-induced hyperlipidemia in a HIV-patient treated with plasmapheresis in an acute setting. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 13:24:49