Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Conversion of atrial fibrillation by the experimental antiarrhythmic drug tedisamil in two canine models
Autore:
Fischbach, PS; Barrett, TD; Goyal, R; Tran, BC; Syed, ZA; Hennan, JK; Lucchesi, BR;
Indirizzi:
Univ Michigan, Sch Med, Dept Pharmacol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 t Pharmacol, Ann Arbor, MI 48109 USA Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 nternal Med, Ann Arbor, MI 48109 USA Univ Michigan, Sch Med, Dept Pediat & Communicable Dis, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 nicable Dis, Ann Arbor, MI 48109 USA
Titolo Testata:
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
fascicolo: 10, volume: 12, anno: 2001,
pagine: 1138 - 1144
SICI:
1045-3873(200110)12:10<1138:COAFBT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
OUTWARD K+ CURRENT; SMOOTH-MUSCLE CELLS; PIG PORTAL-VEIN; VENTRICULAR-FIBRILLATION; POTASSIUM CHANNEL; QT INTERVAL; CLINICAL-EXPERIENCE; IMPLANTABLE ATRIAL; HEART; TRANSIENT;
Keywords:
atrial fibrillation; antiarrhythmic drugs; tedisamil; animal model;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Fischbach, PS Univ Michigan, Sch Med, Dept Pharmacol, 1301 MSRB 3, Ann Arbor, MI 48109 USA Univ Michigan 1301 MSRB 3 Ann Arbor MI USA 48109 I 48109 USA
Citazione:
P.S. Fischbach et al., "Conversion of atrial fibrillation by the experimental antiarrhythmic drug tedisamil in two canine models", J CARD ELEC, 12(10), 2001, pp. 1138-1144

Abstract

Tedisamil Conversion of AF in Two Canine Models. Introduction: Tedisamil is an experimental bradycardic agent possessing action potential-prolonging effects. It has been proven effective in terminating ventricular arrhythmias in several animal models and atrial flutter in a conscious dog model. There are no reports to date evaluating tedisamills efficacy in terminating atrial fibrillation (AF). Methods and Results: Two different canine models of AF were used. One group of dogs (n = 6) was subjected to 28 days of chronic fibrillatory pacing at 50 Hz using an implantable neural stimulator. Sustained AF was achieved in all dogs within 14 days of initiating pacing. A second set of dogs (n = 5) had AF induced via bilateral vagal stimulation. Tedisamil 1 mg/kg was 100% effective in terminating AF in both models. Cardioversion was associated with a statistically significant prolongation of the fibrillatory cycle length immediately before return to normal sinus rhythm in both models. A dose-response trial was performed in the vagal AF group as well as in a second group of three dogs that underwent chronic fibrillatory pacing. The efficacy of tedisamil was dose dependent, with limited efficacy at 0.1 and 0.3 mg/kg intravenously in both models. Tedisamil was able to prevent reinduction of sustained AF 30 minutes after administration of 1 mg/kg in the chronic pacing model in all dogs. Side effects included minor hypersalivation in most dogs receiving the I mg/kg dose. No ventricular ectopy or arrhythmias were observed. Conclusion: Tedisamil is effective for conversion of sustained AF to normal sinus rhythm in two different models of AF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:43:21