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Titolo:
Normothermic versus hypothermic cardiopulmonary bypass during repair of congenital heart disease
Autore:
Rasmussen, LS; Sztuk, F; Christiansen, M; Elliott, MJ;
Indirizzi:
Univ Copenhagen Hosp, Ctr Head & Orthoped, Dept Cardiothorac Anesthesia, Rigshosp, DK-2100 Copenhagen, Denmark Univ Copenhagen Hosp Copenhagen Denmark DK-2100 2100 Copenhagen, Denmark Statens Serum Inst, Dept Clin Biochem, DK-2300 Copenhagen, Denmark StatensSerum Inst Copenhagen Denmark DK-2300 K-2300 Copenhagen, Denmark Great Ormond St Hosp Children, Dept Cardiothorac Surg, London WC1N 3JH, England Great Ormond St Hosp Children London England WC1N 3JH WC1N 3JH, England
Titolo Testata:
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
fascicolo: 5, volume: 15, anno: 2001,
pagine: 563 - 566
SICI:
1053-0770(200110)15:5<563:NVHCBD>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURON-SPECIFIC ENOLASE; CORONARY-ARTERY BYPASS; CENTRAL-NERVOUS-SYSTEM; CEREBROSPINAL-FLUID; CARDIAC-SURGERY; S-100 PROTEIN; DYSFUNCTION; SERUM; DAMAGE; BLOOD;
Keywords:
cardiac surgery; pediatric; brain damage; hypothermia; neuron-specific enolase; S-100 beta protein; bleeding;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Rasmussen, LS Univ Copenhagen Hosp, Ctr Head & Orthoped 4132, Dept Anesthesia, Rigshosp,DK-2100 Copenhagen, Denmark Univ Copenhagen Hosp CopenhagenDenmark DK-2100 n, Denmark
Citazione:
L.S. Rasmussen et al., "Normothermic versus hypothermic cardiopulmonary bypass during repair of congenital heart disease", J CARDIOTHO, 15(5), 2001, pp. 563-566

Abstract

Objective: To compare normothermic cardiopulmonary bypass (CPB) versus hypothermic CPB in pediatric patients undergoing repair of congenital heart disease with focus on biochemical markers for brain damage. Design: Prospective randomized interventional study. Setting: Postgraduate teaching hospital. Participants: Twenty patients undergoing repair of congenital heart disease. Interventions: Patients were randomized to normothermic (36 degreesC) versus hypothermic (25 degreesC) CPB. Serum levels of neuron-specific enolase (NSE) and S-100 beta protein were measured in all patients before surgery, immediately after CPB, and 12 and 24 hours after surgery. Blood loss and time for extubation of the trachea were recorded. Measurements andMain Results: Before operation, the S-100 beta protein and NSE levels weresimilar in the 2 groups. The S-100 beta protein serum level increased significantly after CPB in both groups, whereas no change was found in the NSE level. There was no difference in the change of NSE and S-100 beta protein levels between normothermic and hypothermic CPB. Blood loss was significantly less after hypothermic CPB (25 mL/kg/24 h v 42 mL/kg/24 h). Time for extubation was similar. Conclusion: No difference was found in the release of brain-specific proteins between normothermic and hypothermic CPB, but blood loss was higher after normothermic CPB. Copyright (C) 2001 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:31:46