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Titolo:
Polymyositis evolving after rhabdomyolysis associated with HMG-CoA reductase inhibitors: A report of two cases
Autore:
Gupta, S; Blaivas, M; Ike, RW; Crofford, LJ;
Indirizzi:
Univ Michigan, Med Ctr, Dept Internal Med, Div Rheumatol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 v Rheumatol, Ann Arbor, MI 48109 USA Univ Michigan, Med Ctr, Dept Pathol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 Dept Pathol, Ann Arbor, MI 48109 USA
Titolo Testata:
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
fascicolo: 5, volume: 7, anno: 2001,
pagine: 332 - 335
SICI:
1076-1608(200110)7:5<332:PEARAW>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
MITOCHONDRIAL MYOPATHY; SIMVASTATIN; PRAVASTATIN; DERMATOMYOSITIS;
Keywords:
myositis; atorvastatin; cerivastatin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Crofford, LJ Univ Michigan, Med Ctr, Dept Internal Med, Div Rheumatol, 5510E MSRB 1,1150 W Med Ctr Dr, Ann Arbor, MI 48109 USA Univ Michigan 5510E MSRB 1,1150 W Med Ctr Dr Ann Arbor MI USA 48109
Citazione:
S. Gupta et al., "Polymyositis evolving after rhabdomyolysis associated with HMG-CoA reductase inhibitors: A report of two cases", JCR-J CLIN, 7(5), 2001, pp. 332-335

Abstract

3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are commonly used for treatment of hyperlipidemia and its deleterious effects. Myotoxicity has been associated with use of these agents. We report two cases of inflammatory myopathy in patients receiving these agents that did not respond to drug withdrawal and required immunosuppressive treatment. One ofthese patients developed an antibody to histidyl tRNA synthetase or Jo-1, an autoantibody associated With idiopathic inflammatory myopathies. We suggest that HMG-CoA reductase inhibitor-associated myotoxicity may trigger an immune-mediated inflammatory myopathy. Patients whose muscle abnormalities do not resolve with drug withdrawal should be considered for muscle biopsy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 14:28:41