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Titolo:
Phase II evaluation of protracted infusion of cisplatin and 5-fluorouracilin advanced squamous cell carcinoma of the esophagus: a Japan Esophageal Oncology Group (JEOG) trial (JCOG9407)
Autore:
Hayashi, K; Ando, N; Watanabe, H; Ide, H; Nagai, K; Aoyama, N; Takiyama, W; Ishida, K; Isono, K; Makuuchi, H; Imamura, M; Shinoda, M; Ikeuchi, S; Kabuto, T; Yamana, H; Fukuda, H;
Indirizzi:
Tokyo Womens Med Univ, Inst Gastroenterol, Dept Surg, Shinjuku Ku, Tokyo 1628666, Japan Tokyo Womens Med Univ Tokyo Japan 1628666 njuku Ku, Tokyo 1628666, Japan
Titolo Testata:
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
fascicolo: 9, volume: 31, anno: 2001,
pagine: 419 - 423
SICI:
0368-2811(200109)31:9<419:PIEOPI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPH-NODE DISSECTION; THORACIC ESOPHAGUS; CANCER; THERAPY;
Keywords:
esophageal cancer; chemotherapy; cisplatin; phase II study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Hayashi, K Tokyo Womens Med Univ, Inst Gastroenterol, Dept Surg, Shinjuku Ku, 8-1,Kawada Cho, Tokyo 1628666, Japan Tokyo Womens Med Univ 8-1,Kawada Cho Tokyo Japan 1628666 Japan
Citazione:
K. Hayashi et al., "Phase II evaluation of protracted infusion of cisplatin and 5-fluorouracilin advanced squamous cell carcinoma of the esophagus: a Japan Esophageal Oncology Group (JEOG) trial (JCOG9407)", JPN J CLIN, 31(9), 2001, pp. 419-423

Abstract

Background: Surgery for advanced esophageal carcinoma has its limits as regards aggressiveness and therapeutic effect, therefore effective multimodality treatment is required to obtain better survival. The objective of this study was to evaluate whether daily continuous infusion of CDDP could achieve a higher clinical response rate with less toxicity than its drip infusion in the previous phase II study that we had conducted. Methods: Patients with primary extensive or relapsed esophageal carcinoma after esophagectomy, which had distant organ metastasis and histologically proven SCC, were eligible for this study. A dose of 20 mg/m(2) of cisplatinand 800 mg/m(2) of 5-fluorouracil was given by continuous infusion for 24 h on days 1-5. This treatment was repeated every 4 weeks for up to four cycles. A total of 36 men and six women with a median age of 64 (range 39-75) years were registered and 36 patients were eligible. Results: The overall response rate of the registered patients was 33.3% (12/36) and the median response duration was 175 days. Median survival time was 201.5 days and the 1-year survival rate was 27.8%. Change from bolus to continuous infusion of cisplatin affected neither the type nor the degree of toxicity. Conclusion: Daily continuous infusion of cisplatin was not associated withhigher response or lower toxicity than those seen with the high-dose bolusor multibolus treatment regimens. We conclude that this regimen in this setting is not worthy of further phase III trials. JEOG is now evaluating other drug combination regimens.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 21:38:45