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Titolo:
Inflammatory pseudotumor of lymph nodes - Clinicopathologic and immunohistological study of 11 Japanese cases
Autore:
Kojima, M; Nakamura, S; Shimizu, K; Hosomura, Y; Ohno, Y; Itoh, H; Yamane, N; Yoshida, K; Masawa, N;
Indirizzi:
Dokkyo Univ, Sch Med, Dept Pathol, Mibu, Tochigi 3210293, Japan Dokkyo Univ Mibu Tochigi Japan 3210293 thol, Mibu, Tochigi 3210293, Japan Aichi Canc Ctr Hosp, Dept Pathol & Genet, Nagoya, Aichi 464, Japan Aichi Canc Ctr Hosp Nagoya Aichi Japan 464 enet, Nagoya, Aichi 464, Japan Ashikaga Red Cross Hosp, Dept Pathol & Clin Labs, Ashikaga, Japan AshikagaRed Cross Hosp Ashikaga Japan hol & Clin Labs, Ashikaga, Japan Sano Welfare Gen Hosp, Dept Pathol & Clin Labs, Sano, Japan Sano Welfare Gen Hosp Sano Japan , Dept Pathol & Clin Labs, Sano, Japan Tone Cent Hosp, Dept Pathol, Numata, Japan Tone Cent Hosp Numata JapanTone Cent Hosp, Dept Pathol, Numata, Japan Maebashi Red Cross Hosp, Dept Pathol & Clin Labs, Maebashi, Gumma, Japan Maebashi Red Cross Hosp Maebashi Gumma Japan abs, Maebashi, Gumma, Japan Kiryu Welfare Gen Hosp, Dept Pathol & Clin Labs, Kiryu, Gumma, Japan KiryuWelfare Gen Hosp Kiryu Gumma Japan Clin Labs, Kiryu, Gumma, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
fascicolo: 3, volume: 9, anno: 2001,
pagine: 207 - 214
SICI:
1066-8969(200107)9:3<207:IPOLN->2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
LARGE-CELL LYMPHOMA; EXPRESSION; ANTIGEN; CD56;
Keywords:
inflammatory pseudotumor; lymph node; immunohistochemistry; myofibroblasts; vascular endothelial growth factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Kojima, M Dokkyo Univ, Sch Med, Dept Pathol, Mibu, Tochigi 3210293, Japan Dokkyo Univ Mibu Tochigi Japan 3210293 , Tochigi 3210293, Japan
Citazione:
M. Kojima et al., "Inflammatory pseudotumor of lymph nodes - Clinicopathologic and immunohistological study of 11 Japanese cases", INT J SUR P, 9(3), 2001, pp. 207-214

Abstract

We report 11 Japanese cases of inflammatory pseudotumor (IPT) of the lymphnode. There were 7 mates and 4 females with ages ranging from 5 to 68 years (median; 48). Only 2 patients had systemic lymphadenopathy, and all others had involvement of only I lymph node group. Constitutional symptoms such as fever were present in 8 patients and laboratory abnormalities were detected in 5. All patients recovered and were alive and well after 2 to 180 months (median; 32 months). Histologically, the process mainly involved the connective tissue framework of the lymph node, secondarily spreading into thelymph node parenchyma and the perinodal tissue. It was characterized by a storiform growth pattern of myofibroblasts, marked vascularity with associated vascular lesions, and a polymorphous reactive cellular infiltrate in a collagen-rich stroma. An immunohistochemical study revealed numerous myofibroblasts, histiocytes, and vascular endothelial cells expressing vascular endothelial growth factor (VEGF) in 6 cases. It was suggested that VEGF may be involved, in part, in the induction of the angiogenesis of IPT. Moreover, the present study indicates that follicular dendritic cell sarcoma, nasalT/natural killer cell lymphoma, and anaplastic large cell lymphoma should be added to the differential diagnosis from IPT of the lymph node.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 08:25:30