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Titolo:
Proliferating cell nuclear antigen (PCNA): ringmaster of the genome
Autore:
Paunesku, T; Mittal, S; Protic, M; Oryhon, J; Korolev, SV; Joachimiak, A; Woloschak, GE;
Indirizzi:
Argonne Natl Lab, Biosci Div, Argonne, IL 60439 USA Argonne Natl Lab Argonne IL USA 60439 , Biosci Div, Argonne, IL 60439 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
fascicolo: 10, volume: 77, anno: 2001,
pagine: 1007 - 1021
SICI:
0955-3002(200110)77:10<1007:PCNA(R>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEOTIDE EXCISION-REPAIR; DNA-POLYMERASE-DELTA; DEPENDENT KINASE INHIBITOR; PURIFIED HUMAN PROTEINS; MESSENGER-RNA LEVELS; REPLICATION-FACTOR-C; STRAND BREAK REPAIR; GENE ENCODING PCNA; MISMATCH REPAIR; TRANSCRIPTIONAL ACTIVATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
130
Recensione:
Indirizzi per estratti:
Indirizzo: Woloschak, GE Argonne Natl Lab, Biosci Div, 9700 S Cass Ave, Argonne, IL 60439 USA Argonne Natl Lab 9700 S Cass Ave Argonne IL USA 60439 39 USA
Citazione:
T. Paunesku et al., "Proliferating cell nuclear antigen (PCNA): ringmaster of the genome", INT J RAD B, 77(10), 2001, pp. 1007-1021

Abstract

Proliferating cell nuclear antigen (PCNA) protein is one of the central molecules responsible for decisions of life and death of the cell. The PCNA gene is induced by p53, while PCNA protein interacts with p53-controlled proteins Gadd45, MyD118, CR6 and, most importantly, p21, in the process of deciding cell fate. If PCNA protein is present in abundance in the cell in theabsence of p53, DNA replication occurs. On the other hand, if PCNA proteinlevels are high in the cell in the presence of p53, DNA repair takes place. If PCNA is rendered non-functional or is absent or present in low quantities in the cell, apoptosis occurs. The evolution from prokaryotes to eukaryotes involved a change of function of PCNA from a 'simple' sliding clamp protein of the DNA polymerase complex to an executive molecule controlling critical cellular decision pathways. The evolution of multicellular organismsled to the development of multicellular processes such as differentiation,senescence and apoptosis. PCNA, already an essential molecule in the life of single cellular organisms, then became a protein critical for the survival of multicellular organisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 11:15:18