Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
In vivo staphylococcal superantigen-driven polyclonal Ig responses in mice: dependence upon CD4(+) cells and human MHC class II
Autore:
Stohl, W; Xu, D; Zang, S; Kim, KS; Li, L; Hanson, JA; Stohlman, SA; David, CS; Jacob, CO;
Indirizzi:
Univ So Calif, Div Rheumatol & Immunol, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 Immunol, Los Angeles, CA 90033 USA Univ So Calif, Dept Med, Div Gastrointestinal & Liver Dis, Los Angeles, CA90033 USA Univ So Calif Los Angeles CA USA 90033 iver Dis, Los Angeles, CA90033 USA Univ So Calif, Keck Sch Med, Dept Neurol, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 Neurol, Los Angeles, CA 90033 USA Mayo Clin & Mayo Fdn, Dept Immunol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 unol, Rochester, MN 55905 USA
Titolo Testata:
INTERNATIONAL IMMUNOLOGY
fascicolo: 10, volume: 13, anno: 2001,
pagine: 1291 - 1300
SICI:
0953-8178(200110)13:10<1291:IVSSPI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLLAGEN-INDUCED ARTHRITIS; HUMAN B-CELLS; AUREUS TOXIN SUPERANTIGENS; SHOCK SYNDROME TOXIN-1; MATURE T-CELLS; ENTEROTOXIN-B; TRANSGENIC MICE; MICROBIAL SUPERANTIGENS; HLA-DRB1 POLYMORPHISM; LYMPHOCYTES-T;
Keywords:
CD8(+) cells; staphylococcal enterotoxin B; transgenic/knockout mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Stohl, W Univ So Calif, Div Rheumatol & Immunol, 2011 Zonal Ave,HMR 711, Los Angeles, CA 90033 USA Univ So Calif 2011 Zonal Ave,HMR 711 Los Angeles CA USA 90033 USA
Citazione:
W. Stohl et al., "In vivo staphylococcal superantigen-driven polyclonal Ig responses in mice: dependence upon CD4(+) cells and human MHC class II", INT IMMUNOL, 13(10), 2001, pp. 1291-1300

Abstract

Staphylococcal enterotoxin (SE) B and seven other staphylococcal superantigens (SAg), despite promoting vigorous Ig production in human peripheral blood mononuclear cell cultures, are exceedingly poor at eliciting Ig responses in cultures of spleen cells from C57BL/10J (B10) or C3H/HeJ mice. In contrast, SEB elicits Ig responses in cultures of spleen cells from human MHC class II-transgenic mice. Whereas Lp. administration of SEB (0.2-20 mug) tonon-transgenic B10 mice elicits very weak in vivo Ig responses, identical treatment of CD4(+) cell-intact (but not CD4(+) cell-depleted) human MHC class II-transgenic mice elicits dramatic increases in both splenic Ig-secreting cells and serum Ig levels. Over a 2-week period, the SEB-induced in vivo Ig responses peak and then plateau or fall in association with a preferential increase in splenic CD8(+) cells. Nevertheless, in vivo depletion of CD8(+) cells has no sustained effect on SEB-driven Ig responses. Taken together, these observations demonstrate that the effects of SAg on in vivo humoral immune responses are highly CD4(+) cell dependent, are substantially CD8(+) cell independent and can be successfully investigated using human MHC class II-transgenic mice. This model system may be useful in investigating the polyclonally activating effects of microbial products (prototypic environmental insults) on the development of systemic autoimmunity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 10:35:46