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Titolo:
Inhibition of mucosal and systemic T(h)2-type immune responses by intranasal peptides containing a dominant T cell epitope of the allergen Der p 1
Autore:
Jarnicki, AG; Tsuji, T; Thomas, WR;
Indirizzi:
Univ Western Australia, Ctr Child Hlth Res, Perth, WA 6872, Australia UnivWestern Australia Perth WA Australia 6872 Perth, WA 6872, Australia Univ Western Australia, Dept Microbiol, TVW Telethon Inst Child Hlth Res, Perth, WA 6872, Australia Univ Western Australia Perth WA Australia 6872 Perth, WA 6872, Australia Fujita Hlth Univ, Sch Med, Dept Microbiol, Toyoake, Aichi 47011, Japan Fujita Hlth Univ Toyoake Aichi Japan 47011 l, Toyoake, Aichi 47011, Japan
Titolo Testata:
INTERNATIONAL IMMUNOLOGY
fascicolo: 10, volume: 13, anno: 2001,
pagine: 1223 - 1231
SICI:
0953-8178(200110)13:10<1223:IOMAST>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; DUST MITE ALLERGEN; EPITHELIAL-CELLS; IMMUNOLOGICAL-TOLERANCE; ADHESION MOLECULE-1; MYASTHENIA-GRAVIS; LYMPHOID-TISSUE; MESSENGER-RNA; UP-REGULATION; MURINE MODEL;
Keywords:
inhibition; Der p 1; IgE; peptides; intranasal;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Thomas, WR Univ Western Australia, Ctr Child Hlth Res, POB 855, Perth, WA 6872, Australia Univ Western Australia POB 855 Perth WA Australia 6872 ustralia
Citazione:
A.G. Jarnicki et al., "Inhibition of mucosal and systemic T(h)2-type immune responses by intranasal peptides containing a dominant T cell epitope of the allergen Der p 1", INT IMMUNOL, 13(10), 2001, pp. 1223-1231

Abstract

Although the Intranasal administration of peptides containing T cell epitopes has been shown to be a potent method of inhibiting responses to the allergen Der p 1, the experiments to date have concentrated on their ability to regulate immune responses to the injection of antigen in a T(h)1-type adjuvant. Their ability to regulate responses to a T(h)2-type immunization andto sensitization via the respiratory mucosa has not been examined. Here itis shown that peptide used in doses required to block delayed-type hypersensitivity can also readily inhibit IgE responses to Der p 1 Injected in alum. To examine responses induced in the respiratory mucosa, mice pretreated with intranasal peptide were sensitized with an intranasal dose of Der p 1 in conjunction with a mutated enterotoxin adjuvant. Intranasal peptide evenin very high doses did not reduce IgE titers, but the ability of cells from the draining lymph nodes to release IL-4 and IL-13 but not IL-2, IL-5, IL-10 or IFN-gamma was reduced. These are the first reports on the effect of intranasal peptides; containing T cell epitopes on IgE in T(h)2 immunization and on responses to respiratory immunization. Thus the effect of the peptide-induced mucosal tolerance differs depending on the type of immunizationused for sensitization, but the potential to inhibit T(h)2 responses and responses to respiratory sensitization as well as T(h)1 responses has been demonstrated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 05:38:24