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Titolo:
Enhanced antimycobacterial response to recombinant Mycobacterium bovis BCGexpressing latency-associated peptide
Autore:
Marshall, BG; Wangoo, A; OGaora, P; Cook, HT; Shaw, RJ; Young, DB;
Indirizzi:
Southampton Univ Hosp NHS Trust, Dept Resp Med, Southampton, Hants, England Southampton Univ Hosp NHS Trust Southampton Hants England Hants, England Natl Heart & Lung Inst, Dept Resp Med, London, England Natl Heart & Lung Inst London England t, Dept Resp Med, London, England Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Pathol, London,England Univ London Imperial Coll Sci Technol & Med London England ndon,England Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Infect Dis & Microbiol, London, England Univ London Imperial Coll Sci Technol & Med London England don, England
Titolo Testata:
INFECTION AND IMMUNITY
fascicolo: 11, volume: 69, anno: 2001,
pagine: 6676 - 6682
SICI:
0019-9567(200111)69:11<6676:EARTRM>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; TRANSFORMING GROWTH-FACTOR-BETA-1; IFN-GAMMA; TGF-BETA; TUBERCULOSIS; IMMUNITY; FACTOR-BETA-1; INTERLEUKIN-2; METAANALYSIS; MACROPHAGES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Marshall, BG Southampton Univ Hosp NHS Trust, Dept Resp Med, Southampton, Hants, England Southampton Univ Hosp NHS Trust Southampton Hants England d
Citazione:
B.G. Marshall et al., "Enhanced antimycobacterial response to recombinant Mycobacterium bovis BCGexpressing latency-associated peptide", INFEC IMMUN, 69(11), 2001, pp. 6676-6682

Abstract

With a view to exploring the role of transforming growth factor beta (TGF-beta) during mycobacterial infection, recombinant clones of bacillus Calmette-Guerin (BCG) were engineered to express the natural antagonist of TGF-beta, latency-activated peptide (LAP). Induction of TGF-beta activity was reduced when macrophages were infected with BCG expressing the LAP construct (LAP-BCG). There was a significant reduction in the growth of LAP-BCG in comparison to that of control BCG following intravenous infection in a mouse model. The enhanced control of mycobacterial replication was associated withan increase in the production of gamma interferon by splenocytes challenged during the acute stage of infection but with a diminished recall responseassessed after 13 weeks. Organ weight and hydroxyproline content, representing tissue pathology, were also lower in mice infected with LAP-BCG. The results are consistent with the hypothesis that TGF-beta has a detrimental effect on mycobacterial immunity. While a reduction in TGF-beta activity augments the initial response to BCG vaccination, early bacterial clearance may adversely affect the induction of a long-term memory response by LAP-BCG.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 16:12:17