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Titolo:
Neuroendocrine-immune (NEI) circuitry from neuron-glial interactions to function: Focus on gender and HPA-HPG interactions on early programming of the NEI system
Autore:
Morale, MC; Gallo, F; Tirolo, C; Testa, N; Caniglia, S; Marletta, N; Spina-Purrello, V; Avola, R; Caucci, F; Tomasi, P; Delitala, G; Barden, N; Marchetti, B;
Indirizzi:
Univ Sassari, Sch Med, Dept Pharmacol, I-07100 Sassari, Italy Univ Sassari Sassari Italy I-07100 ept Pharmacol, I-07100 Sassari, Italy OASI Inst IRCCS Res & Care Mental Retardat & Brai, Dept Neuropharmacol, I-94018 Troina, EN, Italy OASI Inst IRCCS Res & Care Mental Retardat & Brai Troina EN Italy I-94018 Univ Sassari, Sch Med, Dept Endocrinol, I-07100 Sassari, Italy Univ Sassari Sassari Italy I-07100 pt Endocrinol, I-07100 Sassari, Italy Univ Catania, Catania, Italy Univ Catania Catania ItalyUniv Catania, Catania, Italy Univ Laval, Dept Anat & Physiol, Quebec City, PQ, Canada Univ Laval Quebec City PQ Canada Anat & Physiol, Quebec City, PQ, Canada
Titolo Testata:
IMMUNOLOGY AND CELL BIOLOGY
fascicolo: 4, volume: 79, anno: 2001,
pagine: 400 - 417
SICI:
0818-9641(200107)79:4<400:N(CFNI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE-RELEASING HORMONE; PITUITARY-ADRENAL AXIS; GLUCOCORTICOID-RECEPTOR FUNCTION; LUTEINIZING-HORMONE; GENE-EXPRESSION; LHRH RECEPTORS; MESSENGER-RNA; RAT-BRAIN; REPRODUCTIVE PHYSIOPATHOLOGY; ADRENOCORTICAL SYSTEM;
Keywords:
corticotropin releasing factor; gender; hypothalamic-pituitary-adrenocortical (HPA) axis; hypothalamic- pituitary-gonadal (HPG) axis; luteinizing hormone-releasing hormone (LHRH); neuron-glial interactions; stress;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
130
Recensione:
Indirizzi per estratti:
Indirizzo: Marchetti, B Univ Sassari, Sch Med, Dept Pharmacol, I-07100 Sassari, ItalyUniv Sassari Sassari Italy I-07100 , I-07100 Sassari, Italy
Citazione:
M.C. Morale et al., "Neuroendocrine-immune (NEI) circuitry from neuron-glial interactions to function: Focus on gender and HPA-HPG interactions on early programming of the NEI system", IMM CELL B, 79(4), 2001, pp. 400-417

Abstract

Bidirectional communication between the neuroendocrine and immune systems during ontogeny plays a pivotal role in programming the development of neuroendocrine and immune responses in adult life. Signals generated by the hypothalamic-pituitary-gonadal axis (i.e. luteinizing hormone-releasing hormone, LHRH, and sex steroids), and by the hypothalamic-pituitary-adrenocortical axis (glucocorticoids (GC)), are major players coordinating the development of immune system function. Conversely, products generated by immune system activation exert a powerful and long-lasting regulation on neuroendocrine axes activity. The neuroendocrine-immune system is very sensitive to preperinatal experiences, including hormonal manipulations and immune challenges, which may influence the future predisposition to several disease entities. We review our work on the ongoing mutual regulation of neuroendocrine and immune cell activities, both at a cellular and molecular level. In the central nervous system, one chief compartment is represented by the astroglial cell and its mediators. Hence, neuron-glial signalling cascades dictate major changes in response to hormonal manipulations and pro-inflammatory triggers. The interplay between LHRH, sex steroids, GC and pro-inflammatory mediators in some physiological and pathological states, together with the potential clinical implications of these findings, are summarized. The overall study highlights the plasticity of this intersystem cross-talk for pharmacological targeting with drugs acting at the neuroendocrine-immune interface.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:28:52