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Titolo:
Towards a unified model of neuroendocrine-immune interaction
Autore:
Petrovsky, N;
Indirizzi:
Univ Canberra, Div Sci & Design, Canberra, ACT, Australia Univ Canberra Canberra ACT Australia & Design, Canberra, ACT, Australia Univ Sydney, Canberra Clin Sch, Autoimmun Res Unit, Canberra, ACT, Australia Univ Sydney Canberra ACT Australia un Res Unit, Canberra, ACT, Australia
Titolo Testata:
IMMUNOLOGY AND CELL BIOLOGY
fascicolo: 4, volume: 79, anno: 2001,
pagine: 350 - 357
SICI:
0818-9641(200107)79:4<350:TAUMON>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENAL AXIS; VASOACTIVE-INTESTINAL-PEPTIDE; GAMMA-INTERFERON PRODUCTION; PINEAL HORMONE MELATONIN; NECROSIS-FACTOR-ALPHA; HUMAN LYMPHOCYTES-T; RHEUMATOID-ARTHRITIS; CYTOKINE PRODUCTION; NOCTURNAL ASTHMA; HUMAN-MONOCYTES;
Keywords:
cytokine; immune; neuroendocrine; regulation; T-cell subsets;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
91
Recensione:
Indirizzi per estratti:
Indirizzo: Petrovsky, N Canberra Hosp, NHSC Autoimmun Res Unit, POB 11, Woden, ACT 2606, Australia Canberra Hosp POB 11 Woden ACT Australia 2606 2606, Australia
Citazione:
N. Petrovsky, "Towards a unified model of neuroendocrine-immune interaction", IMM CELL B, 79(4), 2001, pp. 350-357

Abstract

Although the neuroendocrine system has immunomodulating potential, studiesexamining the relationship between stress, immunity and infection have, until recently, largely been the preserve of behavioural psychologists. Over the last decade, however, immunologists have begun to increasingly appreciate that neuroendocrine-immune interactions hold the key to understanding the complex behaviour of the immune system in vivo. The nervous, endocrine and immune systems communicate bidirectionally via shared messenger moleculesvariously called neurotransmitters, cytokines or hormones. Their classification as neurotransmitters, cytokines or hormones is more serendipity than a true reflection of their sphere of influence. Rather than these systems being discrete entities we would propose that they constitute, in reality, asingle higher-order entity. This paper reviews current knowledge of neuroendocrine-immune interaction and uses the example of T-cell subset differentiation to show the previously under-appreciated importance of neuroendocrine influences in the regulation of immune function and, in particular, Th1/Th2 balance and diurnal variation there of.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 10:13:31