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Titolo:
Cloning and characterization of a mouse homologue of the human haematopoietic cell-specific four-transmembrane gene HTm4
Autore:
Hulett, MD; Pagler, E; Hornby, JR;
Indirizzi:
Australian Natl Univ, John Curtin Sch Med Res, Div Cell Biol & Immunol, Canberra, ACT 2601, Australia Australian Natl Univ Canberra ACT Australia 2601 rra, ACT 2601, Australia
Titolo Testata:
IMMUNOLOGY AND CELL BIOLOGY
fascicolo: 4, volume: 79, anno: 2001,
pagine: 345 - 349
SICI:
0818-9641(200107)79:4<345:CACOAM>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
FC-EPSILON-RI; AFFINITY IGE RECEPTOR; BETA-SUBUNIT; IMMUNOGLOBULIN-E; GAMMA-RIII; CD20; AMPLIFIER; SURFACE; CDNA; EXPRESSION;
Keywords:
CD20; Fc epsilon RI ss; four-transmembrane; haematopoietic; HTm4;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Hulett, MD Australian Natl Univ, John Curtin Sch Med Res, Div Cell Biol & Immunol, POB 334, Canberra, ACT 2601, Australia Australian Natl Univ POB 334 Canberra ACT Australia 2601 tralia
Citazione:
M.D. Hulett et al., "Cloning and characterization of a mouse homologue of the human haematopoietic cell-specific four-transmembrane gene HTm4", IMM CELL B, 79(4), 2001, pp. 345-349

Abstract

Haematopoietic cell-specific transmembrane-4 (HTm4) is a four-transmembrane protein most closely related to CD20 and the beta subunit of the high affinity receptor for IgE (Fc epsilon RI beta). To date, it has only been described in humans, where it is expressed in haematopoietic cells of both myeloid and lymphoid lineages. The function of HTm4 is unknown; however, as forCD20 and Fc epsilon RI-beta, it is likely to play a role in signal transduction as part of a multi-subunit cell surface receptor complex. In this study, we report the cDNA cloning and expression distribution of mouse HTm4. The deduced mouse HTm4 protein is of 213 amino acids, and contains four putative transmembrane domains. Mouse HTm4 shows 62% overall amino acid identity with human HTm4; the transmembrane regions are highly conserved between both species (75% identity), whereas the N- and C-terminal and inter-transmembrane loop regions are more divergent (52%). Interestingly, the N-terminaldomain of mouse HTm4 is predicted to be 23 amino acids shorter, and the C-terminal domain 23 amino acids longer, than that of human HTm4. Northern blot and reverse transcriptase (RT)-PCR analysis suggest that mouse HTm4 mRNAis expressed at low levels only in spleen, bone marrow and peripheral blood leucocytes. This is the first report of the cloning of HTm4 from a species other than human, and provides important sequence information towards theunderstanding of the function of this poorly characterized four-transmembrane molecule.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 04:08:24