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Titolo:
Optimization of PET system design for lesion detection
Autore:
Qi, JY;
Indirizzi:
Lawrence Berkeley Natl Lab, Ctr Funct Imaging, Berkeley, CA 94720 USA Lawrence Berkeley Natl Lab Berkeley CA USA 94720 , Berkeley, CA 94720 USA
Titolo Testata:
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
fascicolo: 4, volume: 48, anno: 2001,
parte:, 2
pagine: 1470 - 1476
SICI:
0018-9499(200108)48:4<1470:OOPSDF>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HOTELLING TRACE CRITERION; HIGH-RESOLUTION; RECONSTRUCTION ALGORITHMS; MAXIMUM-LIKELIHOOD; NOISE PROPERTIES; SMALL ANIMALS; EM ALGORITHM; TOMOGRAPHY; VARIANCE; EMISSION;
Keywords:
lesion detection; optimization methods; positron emission tomography (PET);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Engineering, Computing & Technology
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Qi, JY Lawrence Berkeley Natl Lab, Ctr Funct Imaging, Berkeley, CA 94720 USA Lawrence Berkeley Natl Lab Berkeley CA USA 94720 ley, CA 94720 USA
Citazione:
J.Y. Qi, "Optimization of PET system design for lesion detection", IEEE NUCL S, 48(4), 2001, pp. 1470-1476

Abstract

Traditionally, the figures of merit used in designing a positron emission tomography (PET) scanner are spatial resolution, noise equivalent count rate, noise equivalent sensitivity, etc. These measures, however, do not directly reflect the lesion detectability using the PET scanner. Here we proposeto optimize PET scanner design directly for lesion detection. The signal-to-noise ratio (SNR) of lesion detection can be easily computed using the theoretical expressions that we have previously derived. Because no time-consuming Monte Carlo simulation is needed, the theoretical expressions allow evaluation of a large range of parameters. The PET system parameters can then be chosen to achieve the maximum SNR for lesion detection. The simulationstudy shown in this paper was focused on a single ring PET scanner withoutdepth of interaction measurement. It can be extended to multiring (two- orthree-dimensional) PET scanners and detectors with depth of interaction measurement.

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Documento generato il 07/07/20 alle ore 05:38:29