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Titolo:
Association between blood pressure and insulin resistance in obese femalesduring weight loss and weight rebound phenomenon
Autore:
Itoh, K; Imai, K; Masuda, T; Abe, S; Tanaka, M; Koga, R; Itoh, H; Nakamura, M;
Indirizzi:
Nakamura Gakuen Univ, Dept Food & Nutr, Hlth Promot Ctr, Jonan Ku, Fukuoka8140198, Japan Nakamura Gakuen Univ Fukuoka Japan 8140198 nan Ku, Fukuoka8140198, Japan
Titolo Testata:
Hypertension research
fascicolo: 5, volume: 24, anno: 2001,
pagine: 481 - 487
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC NEURAL ACTIVATION; NERVOUS-SYSTEM ACTIVITY; GLUCOSE-INTOLERANCE; HYPERTENSION; WOMEN; DIET; HYPERINSULINEMIA; VASODILATION; IMPROVEMENT; SENSITIVITY;
Keywords:
hyperinsulimia; norepinephrine; weight loss; weight rebound; blood pressure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Itoh, K Nakamura Gakuen Univ, Dept Food & Nutr, Hlth Promot Ctr, Jonan Ku,5-7-1 Befu, Fukuoka 8140198, Japan Nakamura Gakuen Univ 5-7-1 Befu Fukuoka Japan 8140198 0198, Japan
Citazione:
K. Itoh et al., "Association between blood pressure and insulin resistance in obese femalesduring weight loss and weight rebound phenomenon", HYPERTENS R, 24(5), 2001, pp. 481-487

Abstract

The purpose of this study was to investigate the effect of weight loss on blood pressure and its related variables in moderately obese Japanese females, including an investigation of the rebound phenomenon. Study I examined the effects of weight loss on blood pressure in 138 moderately obese, nondiabetic females (BMI 29.3 +/- 0.3 kg/m(2); age, 46.3 +/- 0.8 years) during a3-month therapeutic dietary and exercise program. Study II investigated the effect of weight rebound on blood pressure over an additional 21 months of exercise in 48 subjects from Study I subjects. After 3 months, the BMI significantly decreased to 27.9 +/- 0.3 kg/m(2). Abdominal total fat, visceral fat (V), and subcutaneous fat (S) also decreased significantly. In addition, the summation of insulin (Sigma IRI), plasma glucose (Sigma PG) and HOMA during 75 g oral glucose tolerance test also all significantly decreased. Significant decreases in both the SBP and DBP were observed after the 3 month weight reduction program. Multiple regression analysis revealed that the reduction in SBP was significantly and positively associated with the reduction in log ZIA] and the reduction in log 24h-urinary norepinephrine excretion at the end of Study I. The DBP showed a significantly positive association with the log Sigma IRI. With regard to the weight rebound phenomenon,Study II showed that the SBP, DBP and Sigma IRI all increased significantly, and a positive correlation was observed between the changes in the SBP and those in the log Sigma IRI. However, no such correlation was observed regarding the abdominal total fat and visceral fat during both periods. Theseresults suggest that weight loss therefore caused the BP to decrease due to both an improvement in hyperinsulinemia and a decrease in the adrenergic activity which may be involved in the urinary catecholamine. As a result, hyperinsulinemia is thus considered to play an important role in the pathogenesis of blood pressure due to obesity not only during weight loss, but also during the weight rebound phenomenon.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 13:27:19