Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Blood transfusion and postoperative plasma cytokine antagonist levels in colorectal cancer patients
Autore:
Iwagaki, H; Yagi, T; Urushihara, N; Morimoto, Y; Jikuhara, A; Isozaki, H; Tanaka, N;
Indirizzi:
Okayama Univ, Sch Med, Dept Surg 1, Okayama 700, Japan Okayama Univ Okayama Japan 700 Sch Med, Dept Surg 1, Okayama 700, Japan
Titolo Testata:
HEPATO-GASTROENTEROLOGY
fascicolo: 41, volume: 48, anno: 2001,
pagine: 1351 - 1354
SICI:
0172-6390(200109/10)48:41<1351:BTAPPC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR RECEPTOR; INFECTIOUS COMPLICATIONS; IL-1-BETA PRODUCTION; SOLUBLE RECEPTORS; LIVER RESECTION; HUMAN MONOCYTES; SURVIVAL; SURGERY; DISEASE; INTERLEUKIN-1;
Keywords:
colorectal cancer; cytokine antagonist; blood transfusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Iwagaki, H Okayama Univ, Sch Med, Dept Surg 1, 2-5-1 Shikata, Okayama 700,Japan Okayama Univ 2-5-1 Shikata Okayama Japan 700 kayama 700, Japan
Citazione:
H. Iwagaki et al., "Blood transfusion and postoperative plasma cytokine antagonist levels in colorectal cancer patients", HEP-GASTRO, 48(41), 2001, pp. 1351-1354

Abstract

Background/Aims: Postoperative cytokine antagonist response affects various factors. However, excessive stress responses are deleterious as increasedplasma concentration of cytokine antagonists may induce an impaired immunesystem. Methodology: We determined plasma levels of cortisol, IL-1ra, and sTNF-R55in 20 patients who had undergone resection of colorectal carcinoma. Ten patients had a blood transfusion during the operation (invasive group), but 10 patients had received no blood transfusion (less invasive group). Plasma levels of cytokine antagonists were determined before operation (POD 0) andPOD-1, -2 and -7. Results: Postoperative plasma cortisol and sTNF-R55 levels were significantly elevated on POD-1 in the invasive group. Plasma IL-1ra levels were significantly increased on POD-1 in both the invasive and less invasive groups. Conclusions: The present study demonstrated that perioperative allogeneic blood transfusion can induce an excessive production of cortisol and sTNF-R55, and might be deleterious.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:21:36