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Titolo:
Maspin expression in stage I and II oral tongue squamous cell carcinoma
Autore:
Yasumatsu, R; Nakashima, T; Hirakawa, N; Kumamoto, Y; Kuratomi, Y; Tomita, K; Komiyama, S;
Indirizzi:
Kyushu Univ, Fac Med, Dept Otorhinolaryngol, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 ol, Higashi Ku, Fukuoka 8128582, Japan Kyushu Natl Canc Ctr, Div Head & Neck, Fukuoka, Japan Kyushu Natl Canc Ctr Fukuoka Japan Ctr, Div Head & Neck, Fukuoka, Japan
Titolo Testata:
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
fascicolo: 11, volume: 23, anno: 2001,
pagine: 962 - 966
SICI:
1043-3074(200111)23:11<962:MEISIA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR; CANCER CELLS; SERPIN; PHENOTYPE; MAMMARY; EMBRYO; CAVITY; RAT;
Keywords:
maspin; serine protease inhibitor; early tongue carcinoma; immunohistochemistry; metastasis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Yasumatsu, R Kyushu Univ, Fac Med, Dept Otorhinolaryngol, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan Kyushu Univ 3-1-1 Maidashi Fukuoka Japan 8128582 8582, Japan
Citazione:
R. Yasumatsu et al., "Maspin expression in stage I and II oral tongue squamous cell carcinoma", HEAD NECK, 23(11), 2001, pp. 962-966

Abstract

Background. A relatively high failure rate in the therapy of patients withearly oral tongue squamous cell carcinomas (SCCs) is evidenced by untreated clinically negative neck lymph node metastasis. It is important to predict the malignant potential of oral tongue SCC in stage I and If patients, because the development of lymph node metastasis directly affects the prognosis of the patients. Methods. We evaluated maspin expression immunohistochemically in patients with stage I and II oral tongue SCCs and determined whether the expression level may be a useful factor in predicting metastatic potential and prognosis of these SCCs. Results. Clinical follow-up data showed a longer disease-free interval andoverall survival periods for tumors immunohistochemically positive for maspin than for tumors negative for maspin, with the difference in disease-free interval being statistically significant (p = .01). The absence of maspinexpression was found more frequently in cases of subsequent cervical lymphnode metastasis than in cases without metastasis (p = .03). Conclusions. Decreased maspin expression may be a significant factor associated with the metastatic potential of stage I and II oral tongue SCCs. (C)2001 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 23:44:19