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Titolo:
Acute gastrointestinal permeability responses to different non-steroidal anti-inflammatory drugs
Autore:
Smecuol, E; Bai, JC; Sugai, E; Vazquez, H; Niveloni, S; Pedreira, S; Maurino, E; Meddings, J;
Indirizzi:
Salvador Univ, C Bonorino Udaondo Gastroenterol Hosp, Clin Serv, Small Intestinal Sect, RA-1264 Buenos Aires, DF, Argentina Salvador Univ Buenos Aires DF Argentina RA-1264 enos Aires, DF, Argentina Univ Calgary, GI Res Grp, Calgary, AB, Canada Univ Calgary Calgary AB Canada Calgary, GI Res Grp, Calgary, AB, Canada
Titolo Testata:
GUT
fascicolo: 5, volume: 49, anno: 2001,
pagine: 650 - 655
SICI:
0017-5749(200111)49:5<650:AGPRTD>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; SMALL INTESTINAL PERMEABILITY; INDOMETHACIN-INDUCED CHANGES; NSAID-ENTEROPATHY; CELIAC-DISEASE; COLITIS; RAT; CYCLOOXYGENASE-1; INHIBITION; NAPROXEN;
Keywords:
permeability; non-steroidal anti-inflammatory drugs; celecoxib; meloxican; small intestine; gastric injury;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Bai, JC Salvador Univ, C Bonorino Udaondo Gastroenterol Hosp, Clin Serv, Small Intestinal Sect, Av Gaseros 2061, RA-1264 Buenos Aires, DF, Argentina Salvador Univ Av Gaseros 2061 Buenos Aires DF Argentina RA-1264 na
Citazione:
E. Smecuol et al., "Acute gastrointestinal permeability responses to different non-steroidal anti-inflammatory drugs", GUT, 49(5), 2001, pp. 650-655

Abstract

Background and aims-Non-steroidal anti-inflammatory drugs (NSAIDs) cause gastrointestinal damage both in the upper and lower gastrointestinal tract. New antiinflammatory drugs have been developed in an attempt to improve their gastrointestinal side effect profile., Our objective was to compare the,effect on gastrointestinal permeability of acute equieffective doses of four different NSAIDs; three were designed to reduce gastrointestinal mucosalinjury. Materials-Healthy volunteers underwent sugar tests in a randomised fashion, 15 days apart, at: (1) baseline; (2) after two days of 75 mg slow release(microspheres) indomethacin; (3) after two days of 7.5 mg oral meloxicam which preferentially inhibits cyclooxygenase 2; and (4), after two days of 750 mg naproxen. A subgroup of subjects was tested after two days of 200 mg celecoxib. In each test, subjects ingested a solution containing sucrose, lactulose, and mannitol and sucralose, to evaluate gastroduodenal, intestinal, and colonic permeability, respectively. Results-Gastric permeability was significantly affected by naproxen (p < 0.05) but not by slow release indomethacin, meloxicam, or celecoxib. Intestinal permeability was significantly increased by the first three NSAIDs (p <0.05) but not by celecoxib. Abnormal lactulose/mannitol ratios were observed in 42% of meloxicam treatments, in 62% during indomethacin, and in 75% of subjects treated with naproxen. Finally, colonic permeability, as measured by sucralose, was not significantly increased by any of the four drugs. Conclusion-Our study provides evidence that the newly developed NSAIDs reduce gastric mucosal permeability significantly. However, most produced significant alteration of small intestinal permeability. In contrast, our results, suggest that celecoxib seems to exhibit the most desirable gastrointestinal side effect profile..

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 12:58:24