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Titolo:
Isoform-specific expression of VEGF-B in normal tissues and tumors
Autore:
Li, XR; Aase, K; Li, H; von Euler, G; Eriksson, U;
Indirizzi:
Ludwig Inst Canc Res, S-17177 Stockholm, Sweden Ludwig Inst Canc Res Stockholm Sweden S-17177 S-17177 Stockholm, Sweden
Titolo Testata:
GROWTH FACTORS
fascicolo: 1, volume: 19, anno: 2001,
pagine: 49 -
SICI:
0897-7194(2001)19:1<49:IEOVIN>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; RECEPTOR-BINDING PROPERTIES; FACTOR FAMILY; MICE LACKING; FACTOR-C; RNA; LOCALIZATION; ANGIOGENESIS; MOUSE; GENE;
Keywords:
VEGF-B; isoform; regulation; tumor; cell line;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Eriksson, U Ludwig Inst Canc Res, Box 240, S-17177 Stockholm, Sweden Ludwig Inst Canc Res Box 240 Stockholm Sweden S-17177 Sweden
Citazione:
X.R. Li et al., "Isoform-specific expression of VEGF-B in normal tissues and tumors", GROW FACTOR, 19(1), 2001, pp. 49

Abstract

Vascular endothelial growth factor B (VEGF-B), a member of the VEGF/PDGF family, is highly expressed in many tissues with two differentially spliced transcripts generating two secreted isoforms, VEGF-B-167 and VEGF-B-186. Inthis work, we have investigated the expression of VEGF-B in tissues and cell lines using techniques that can distinguish the two isoforms. The results showed that the VEGF-B-167 isoform was predominantly expressed in most tissues, accounting for more than 80% of the total VEGF-B transcripts. The VEGF-B-186 isoform was expressed at lower levels and only in a limited numberof tissues. Moreover, the VEGF-B-186 isoform was up-regulated in mouse andhuman tumor cell lines and primary tumors compared with their corresponding normal tissues. Taken together, our data suggest a fine genetic control of the expression of the two isoforms of VEGF-B, implying tissue- and cell-specific roles of the two VEGF-B isoforms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:25:12