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Titolo:
Differential stress induction of individual Alu loci: implications for transcription and retrotransposition
Autore:
Li, TH; Schmid, CW;
Indirizzi:
Univ Calif Davis, Sect Mol & Cellular Biol, Davis, CA 95616 USA Univ CalifDavis Davis CA USA 95616 & Cellular Biol, Davis, CA 95616 USA Univ Calif Davis, Dept Chem, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 Davis, Dept Chem, Davis, CA 95616 USA
Titolo Testata:
GENE
fascicolo: 1-2, volume: 276, anno: 2001,
pagine: 135 - 141
SICI:
0378-1119(20011003)276:1-2<135:DSIOIA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN TRANSPOSABLE ELEMENT; RNA; CELLS; EXPRESSION; SINE; RETROPOSONS; ACTIVATION; SEQUENCES; INCREASE;
Keywords:
short interspersed nuclear element; regulated expression; RNA polymerase III;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Schmid, CW Univ Calif Davis, Sect Mol & Cellular Biol, Davis, CA 95616 USAUniv Calif Davis Davis CA USA 95616 Biol, Davis, CA 95616 USA
Citazione:
T.H. Li e C.W. Schmid, "Differential stress induction of individual Alu loci: implications for transcription and retrotransposition", GENE, 276(1-2), 2001, pp. 135-141

Abstract

While human Alu repeats can be considered to be members of an extremely large, globally regulated, multigene family, each member of this family resides within a different sequence context that might uniquely modulate its transcription. Unique 3' flanking sequences for several transcriptionally active human Alu elements were identified by cDNA cloning and used for primer extension analysis to compare the basal and stress-induced expression of thecorresponding Aln loci. Each of six Alu loci investigated exhibits a unique pattern of expression in three different human cell lines and in responseto stress induction. The sequence context surrounding each Alu member uniquely determines its transcriptional regulation. In many cases, the individual Ain loci and total Alu RNA exhibit opposing patterns of expression implying that local rather than global regulation ultimately determines the expression of individual members. Some of the stresses, which induce Alu transcription, increase co-expression of LINE1 RNA, another requirement for Alu retrotransposition. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 02:23:19