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Titolo:
Neuroendocrine tumor markers
Autore:
Lamberts, SWJ; Hofland, LJ; Nobels, FRE;
Indirizzi:
Erasmus Univ, Dept Med, Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands iv, Dept Med, Rotterdam, Netherlands
Titolo Testata:
FRONTIERS IN NEUROENDOCRINOLOGY
fascicolo: 4, volume: 22, anno: 2001,
pagine: 309 - 339
SICI:
0091-3022(200110)22:4<309:NTM>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURON-SPECIFIC ENOLASE; SOMATOSTATIN RECEPTOR SCINTIGRAPHY; MEDULLARY-THYROID CARCINOMA; ENDOCRINE NEOPLASIA TYPE-1; CELL LUNG-CANCER; GONADOTROPH PITUITARY-ADENOMAS; THYROTROPIN-RELEASING-HORMONE; HUMAN CHORIONIC-GONADOTROPIN; REGULATED SECRETORY PATHWAY; PLASMA CHROMOGRANIN-A;
Keywords:
neuroendocrine tumors; hormones; chromogranin A; neuron-specific enolase; alpha-subunit; somatostatin receptor scintigraphy; tumor markers;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
118
Recensione:
Indirizzi per estratti:
Indirizzo: Lamberts, SWJ Univ Hosp Dijkzigt, Dept Med, 40 Dr Molewaterpl, NL-3015 GD Rotterdam, Netherlands Univ Hosp Dijkzigt 40 Dr Molewaterpl Rotterdam Netherlands NL-3015 GD
Citazione:
S.W.J. Lamberts et al., "Neuroendocrine tumor markers", FRONT NEURO, 22(4), 2001, pp. 309-339

Abstract

Tumor markers used in the diagnosis and follow-up of patients with neuroendocrine tumors are in most instances not specific for a given tumor and circulate under normal conditions in the serum, making their use as an early diagnostic tool difficult (low sensitivity). By combining hormone measurements with tissue responsiveness, demonstrations of inappropriate secretions of PTH, insulin, and gastrin during hypercalcemia, hypoglycemia, and hyperacidity, respectively, become highly sensitive and specific diagnostic tests. The application of polyclonal antibodies in RIAs of hormones, such as ACTH, insulin, and gastrin, increase the diagnostic level of hormone measurements in patients with neuroendocrine tumors. Other markers, such as chromogranin A, neuron-specific enolase, and a-subunit, as well as peptide receptor visualization, are of increasing importance in the diagnosis and follow-up of neuroendocrine and non-neuroendocrine tumors. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:43:45