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Titolo:
Changes in the antitumor resistance of Wistar rats after long-term exposure to radiation in the Chernobyl zone
Autore:
Savtsova, ZD; Fedosova, NI; Voyejkova, IM; Yudina, OY; Novichenko, NL; Indyk, VM;
Indirizzi:
Natl Acad Sci Ukraine, RE Kavetsky Inst Expt Pathol Oncol & Radiobiol, UA-03022 Kiev, Ukraine Natl Acad Sci Ukraine Kiev Ukraine UA-03022 biol, UA-03022 Kiev, Ukraine
Titolo Testata:
EXPERIMENTAL ONCOLOGY
fascicolo: 3, volume: 23, anno: 2001,
pagine: 183 - 188
SICI:
0204-3564(200109)23:3<183:CITARO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
RUS
Soggetto:
TUMOR; INVIVO;
Keywords:
Chernobyl APP zone; Wistar rats; antitumor resistance; dynamics; transformed cells A5;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Savtsova, ZD Natl Acad Sci Ukraine, RE Kavetsky Inst Expt Pathol Oncol & Radiobiol, UA-03022 Kiev, Ukraine Natl Acad Sci Ukraine Kiev Ukraine UA-03022 2 Kiev, Ukraine
Citazione:
Z.D. Savtsova et al., "Changes in the antitumor resistance of Wistar rats after long-term exposure to radiation in the Chernobyl zone", EXP ONCOL, 23(3), 2001, pp. 183-188

Abstract

Antitumor resistance of Wistar rats was studied in terms of dynamic exposure to irradiation in the Chernobyl zone. The antitumor resistance was shownto change in a wave-like manner depending on the duration of exposure: increase (4 mos), restoration of the level which is characteristic of the age control (8 mos), and decrease accompanied by a reduction of the metastasizing rate (16 mos). Based on the dynamics of immunologic indices, characteristics of the growth and metastasizing of tumors induced by transformed cells(A5 cell line), and changes in the phenotypic peculiarities of these cellswhen growing in control and exposed hosts, a conclusion is made that not only changes in the activity of effectors of anti-tumor resistance but also changes in the rate of in vivo selection of highly metastatic variants of cells exert a considerable effect on the course of the tumor process in prolonged exposure to combined irradiation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:42:17