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Titolo:
Impaired neurogenic and endothelium-dependent relaxant responses of corpuscavernosum smooth muscle from hyperthyroid rabbits
Autore:
Ozdemirci, S; Yildiz, F; Utkan, T; Ulak, G; Cetinaslan, B; Erden, F; Gacar, N;
Indirizzi:
Univ Kocaeli, Fac Med, Dept Pharmacol, TR-41900 Derince Kocaeli, Turkey Univ Kocaeli Derince Kocaeli Turkey TR-41900 900 Derince Kocaeli, Turkey Univ Kocaeli, Fac Med, Dept Endocrinol & Metab, TR-41900 Derince Kocaeli, Turkey Univ Kocaeli Derince Kocaeli Turkey TR-41900 900 Derince Kocaeli, Turkey
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 428, anno: 2001,
pagine: 105 - 111
SICI:
0014-2999(20010928)428:1<105:INAERR>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE; NONCHOLINERGIC NEUROTRANSMISSION; CORPORA CAVERNOSA; IMPOTENCE; DISEASE; MEN;
Keywords:
hyperthyroidism; corpus cavernosum; contraction; relaxation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Utkan, T Univ Kocaeli, Fac Med, Dept Pharmacol, TR-41900 Derince Kocaeli, Turkey Univ Kocaeli Derince Kocaeli Turkey TR-41900 ce Kocaeli, Turkey
Citazione:
S. Ozdemirci et al., "Impaired neurogenic and endothelium-dependent relaxant responses of corpuscavernosum smooth muscle from hyperthyroid rabbits", EUR J PHARM, 428(1), 2001, pp. 105-111

Abstract

We investigated the effect of hyperthyroidism on the responsiveness of therabbit corpus cavernosum smooth muscle. In male albino rabbits, hyperthyroidism was established by oral feeding of L-thyroxine at increasing dosages (150-450 mug/kg) over an 8-week period. This treatment produced a stable hyperthyroid state as indicated by the increased serum T-4 levels. The reactivity of corpus cavernosum tissue from hyperthyroid animals and euthyroid control animals was studied in organ chambers. Hyperthyroidism caused impaired neurogenic and endothelium-dependent relaxant responses with decreased E-max and pD(2) values. However, hyperthyroidism had no effect on both phenylephrine- and KCl-induced contractile responses and sodium nitroprusside- and papaverine-induced endothelium-independent relaxant responses, and there was no change in agonist potency. These data indicate that hyperthyroidism may impair both neurogenic and endothelium-dependent relaxation of corporalsmooth muscle, and may contribute to the etiology of impotence. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:50:44