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Titolo:
Levels of pre-kallikrein in resting and stimulated human parotid and submandibular saliva
Autore:
Francis, CA; Hector, MP; Proctor, GB;
Indirizzi:
Univ London, Dept Adult Oral Hlth, Barts & London Sch Med & Dent, London E1 2AD, England Univ London London England E1 2AD Sch Med & Dent, London E1 2AD, England Univ London, Dept Oral Growth & Dev, Barts & London Sch Med & Dent, LondonE1 2AD, England Univ London London England E1 2AD Sch Med & Dent, LondonE1 2AD, England GKT Sch Med & Dent, Secretory & Soft Tissue Res Unit, London, England GKT Sch Med & Dent London England Soft Tissue Res Unit, London, England
Titolo Testata:
EUROPEAN JOURNAL OF ORAL SCIENCES
fascicolo: 5, volume: 109, anno: 2001,
pagine: 365 - 368
SICI:
0909-8836(200110)109:5<365:LOPIRA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLASE;
Keywords:
pre-kallikrein; kallikrein; saliva; human;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Francis, CA Univ London, Dept Adult Oral Hlth, Barts & London Sch Med & Dent, Turner St, London E1 2AD, England Univ London Turner St London EnglandE1 2AD n E1 2AD, England
Citazione:
C.A. Francis et al., "Levels of pre-kallikrein in resting and stimulated human parotid and submandibular saliva", EUR J OR SC, 109(5), 2001, pp. 365-368

Abstract

Salivary tissue kallikrein is stored in an active form in human salivary glands. Pre-kallikrein has been demonstrated in mixed saliva, but it is not clear if the various salivary glands contribute equally. This Study set outto determine if prekallikrein is present in human parotid and submandibular salivas at rest, whether levels change during stimulation, and to comparethe pattern of pre-kallikrein and kallikrein secretion with that or total protein. Resting and citric acid-stimulated parotid and submandibular, and gum-stimulated parotid saliva samples were collected from 6 healthy subjects. Salivary flows were determined gravimetrically. Total protein concentration and kallikrein enzymic activity were assayed using standard techniques. Pre-kallikrein was assayed following trypsinisation of duplicate samples. Pre-kallikrein was present in parotid and submandibular ductal saliva. Proportions of pre-kallikrein and active kallikrein were similar in salivas secreted at rest and during stimulation, and both outputs mirrored protein output in both major glands. Gum-stimulated parotid saliva showed lower activity than resting, and no differences were seen between resting and stimulated submandibular samples.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 18:30:20