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Titolo:
Imaging of the endothelial dysfunction in coronary atherosclerosis
Autore:
Kuikka, JT; Raitakari, OT; Gould, KL;
Indirizzi:
Kuopio Univ Hosp, Dept Clin Physiol & Nucl Med, Kuopio 70210, Finland Kuopio Univ Hosp Kuopio Finland 70210 & Nucl Med, Kuopio 70210, Finland Niuvanniemi Hosp, Kuopio 70210, Finland Niuvanniemi Hosp Kuopio Finland 70210 nniemi Hosp, Kuopio 70210, Finland Turku Univ, Dept Clin Physiol, Turku, Finland Turku Univ Turku FinlandTurku Univ, Dept Clin Physiol, Turku, Finland Turku Univ, Turku PET Ctr, Turku, Finland Turku Univ Turku FinlandTurku Univ, Turku PET Ctr, Turku, Finland Univ Texas, Sch Med, Weatherhead PET Ctr Preventing & Reversing Athero, Houston, TX USA Univ Texas Houston TX USA Preventing & Reversing Athero, Houston, TX USA
Titolo Testata:
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
fascicolo: 10, volume: 28, anno: 2001,
pagine: 1567 - 1578
SICI:
0340-6997(200110)28:10<1567:IOTEDI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; MYOCARDIAL PERFUSION ABNORMALITIES; FAMILIAL COMBINED HYPERLIPIDEMIA; LOW-FAT DIET; ARTERY DISEASE; FLOW RESERVE; YOUNG MEN; IN-VIVO; HEART-DISEASE; NITRIC-OXIDE;
Keywords:
atherosclerosis; endothelium; imaging; myocardium; vasodilation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
100
Recensione:
Indirizzi per estratti:
Indirizzo: Kuikka, JT Kuopio Univ Hosp, Dept Clin Physiol & Nucl Med, Kuopio 70210, Finland Kuopio Univ Hosp Kuopio Finland 70210 , Kuopio 70210, Finland
Citazione:
J.T. Kuikka et al., "Imaging of the endothelial dysfunction in coronary atherosclerosis", EUR J NUCL, 28(10), 2001, pp. 1567-1578

Abstract

Coronary endothelial dysfunction is characterised by coronary vasoconstrictive responses to endothelium-dependent vasodilators. It is associated withcoronary artery disease (CAD) and is considered an early phase of coronaryatherosclerosis. Patients with CAD benefit from vigorous risk factor interventions and medical treatment, with a marked decrease in coronary events and an improvement in survival that are not reported following revascularisation procedures. Therefore, early detection of anatomical and functional changes in the coronary vasculature due to atherosclerosis provides the basisfor integrated pharmacological, dietary and lifestyle modifications to prevent cardiovascular events and revascularisation procedures. The question arises as to whether these alterations in regional myocardial tone can be detected by any of the current non-invasive methods. Several methods are reviewed. We consider that intracoronary ultrasonography is the most accurate method, but non-invasive positron emission tomography and magnetic resonanceimaging technology is of growing importance for identifying endothelial dysfunction of early coronary atherosclerosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:17:59