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Titolo:
The effect of chronic digitalization on pump function in systolic heart failure
Autore:
Hassapoyannes, CA; Easterling, BM; Chavda, K; Chavda, KK; Movahed, MR; Welch, GW;
Indirizzi:
William Jennings Bryan Dorn Vet Affairs Med Ctr, Dept Med, Div Cardiol, Columbia, SC 29209 USA William Jennings Bryan Dorn Vet Affairs Med Ctr Columbia SC USA 29209 USA Univ S Carolina, Dept Med, Div Cardiol, Sch Med, Columbia, SC USA Univ S Carolina Columbia SC USA , Div Cardiol, Sch Med, Columbia, SC USA
Titolo Testata:
EUROPEAN JOURNAL OF HEART FAILURE
fascicolo: 5, volume: 3, anno: 2001,
pagine: 593 - 599
SICI:
1388-9842(200110)3:5<593:TEOCDO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAVENOUS DIGOXIN; MAJOR CAUSE; CALCIUM; VARIABILITY; DYSFUNCTION; MODULATION; MYOCARDIUM; WITHDRAWAL; MORTALITY; TRIAL;
Keywords:
digitalis; heart failure; congestive; ventricular dysfunction, left; systole;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Hassapoyannes, CA William Jennings Bryan Dorn Vet Affairs Med Ctr, Dept Med, Div Cardiol, 6439 Garners Ferry Rd, Columbia, SC 29209 USA William Jennings Bryan Dorn Vet Affairs Med Ctr 6439 Garners Ferry Rd Columbia SC USA 29209
Citazione:
C.A. Hassapoyannes et al., "The effect of chronic digitalization on pump function in systolic heart failure", EUR J HE FA, 3(5), 2001, pp. 593-599

Abstract

Background: Short- and intermediate-term use of cardiac glycosides promotes inotropy and improves the ejection fraction in systolic heart failure. Aim: To determine whether chronic digitalization alters left ventricular function and performance. Methods: Eighty patients with mild-to-moderate systolic heart failure (baseline ejection fraction less than or equal to 45%) participated from our institution in a multi-center, chronic, randomized, double-blind study of digitalis vs. placebo. Of the 40 survivors, 38 (20 allocated to the digitalis arm and 18 to the placebo arm) were evaluated at the end of follow-up (mean, 48.4 months). Left ventricular systolic function wasassessed by both nuclear ventriculography and echocardiography. The ejection fraction was measured scintigraphically, while the ventricular volumes were computed echocardiographically. Results: The groups did not differ, at baseline or end-of-study, with respect to the ejection fraction and the loading conditions (arterial pressure, ventricular volumes and heart rate) by either intention-to-treat or actual-treatment-received analysis. Over the course of the trial, the digitalis arm exhibited no significant increase in the use of diuretics (18%, P = 0.33), in distinction from the placebo group(78%, P = 0.004), and a longer stay on study drug among those patients whowithdrew from double-blind treatment (28.6 vs. 11.4 months, P = 0.01). Conclusion: Following chronic use of digitalis for mild-to-moderate heart failure, cross-sectional comparison with a control group from the same inception cohort showed no appreciable difference in systolic function or performance. Thus, the suggested clinical benefit cannot be explained by an inotropic effect. European Society of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:43:15