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Titolo:
Tumor angiogenesis as a therapeutic target
Autore:
Matter, A;
Indirizzi:
Novartis Pharma AG, Oncol Res, CH-4002 Basel, Switzerland Novartis Pharma AG Basel Switzerland CH-4002 CH-4002 Basel, Switzerland
Titolo Testata:
DRUG DISCOVERY TODAY
fascicolo: 19, volume: 6, anno: 2001,
pagine: 1005 - 1024
SICI:
1359-6446(20011001)6:19<1005:TAAATT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; TYROSINE KINASE INHIBITORS; SQUAMOUS-CELL CARCINOMA; ENDOGENOUS ESTROGEN METABOLITE; VASCULAR-PERMEABILITY FACTOR; ALPHA-V INTEGRINS; FACTOR RECEPTOR; IN-VIVO; ANTIANGIOGENIC THERAPY; PHASE-I;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
156
Recensione:
Indirizzi per estratti:
Indirizzo: Matter, A Novartis Pharma AG, Oncol Res, CH-4002 Basel, Switzerland Novartis Pharma AG Basel Switzerland CH-4002 asel, Switzerland
Citazione:
A. Matter, "Tumor angiogenesis as a therapeutic target", DRUG DISC T, 6(19), 2001, pp. 1005-1024

Abstract

Angiogenesis - the formation of new blood vessels within a tumor (or many other tissue types) - has become a hotbed of pharmacological research as well as industrial drug discovery. This is the result of the efforts of a generation of scientists elucidating the complex (patho) physiological, biochemical and molecular events accompanying angiogenesis. It is estimated that > 300 drug candidates are currently in various stages of testing, and it is, therefore, impossible to capture all of this in a brief review. Therefore, the emphasis here is on relatively advanced projects that are either in preclinical or clinical development, thus neglecting, to a large extent, themany exciting avenues being pursued in both academic and biotechnology laboratories. Although the potential of the approaches described cannot be overestimated, it is also important to note that there is still no drug on themarket that achieves clinical benefit based on a selective modulation or inhibition of angiogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:13:04