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Titolo:
Human disease characterization: real-time quantitative PCR analysis of gene expression
Autore:
Snider, JV; Wechser, MA; Lossos, IS;
Indirizzi:
Appl Biosyst Inc, Foster City, CA 94404 USA Appl Biosyst Inc Foster City CA USA 94404 Inc, Foster City, CA 94404 USA Stanford Univ, Dept Med, Div Oncol, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 ed, Div Oncol, Stanford, CA 94305 USA
Titolo Testata:
DRUG DISCOVERY TODAY
fascicolo: 20, volume: 6, anno: 2001,
pagine: 1062 - 1067
SICI:
1359-6446(20011015)6:20<1062:HDCRQP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MINIMAL RESIDUAL DISEASE; POLYMERASE-CHAIN-REACTION; ACUTE LYMPHOBLASTIC-LEUKEMIA; ACUTE MYELOGENOUS LEUKEMIA; FLUOROGENIC PROBES; FUSION TRANSCRIPTS; MULTIPLE-MYELOMA; RT-PCR; QUANTIFICATION; ASSAY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Snider, JV Appl Biosyst Inc, 850 Lincoln Ctr Dr, Foster City, CA 94404 USAAppl Biosyst Inc 850 Lincoln Ctr Dr Foster City CA USA 94404 SA
Citazione:
J.V. Snider et al., "Human disease characterization: real-time quantitative PCR analysis of gene expression", DRUG DISC T, 6(20), 2001, pp. 1062-1067

Abstract

Real-time quantitative PCR is the measurement of a fluorescent signal generated and measured during PCR as a consequence of amplicon synthesis. When used as reverse transcriptase-PCR (RT-PCR), real-time quantitative PCR has proved to be useful in accurately measuring expression levels of specific gene transcripts. When applied to questions of minimal residual disease, thetechnique has evolved from generically detecting the presence of disease cells in individuals, such as the AML1-ETO fusion transcript, to the identification of a specific gene, such as BCL-6, which is prognostic for determining the therapeutic outcome of patients with diffuse large B-cell lymphoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:54:17