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Titolo:
Cholesterol modulation as an emerging strategy for the treatment of Alzheimer's disease
Autore:
Golde, TE; Eckman, CB;
Indirizzi:
Mayo Clin Jacksonville, Dept Neurosci, Jacksonville, FL 32224 USA Mayo Clin Jacksonville Jacksonville FL USA 32224 cksonville, FL 32224 USA
Titolo Testata:
DRUG DISCOVERY TODAY
fascicolo: 20, volume: 6, anno: 2001,
pagine: 1049 - 1055
SICI:
1359-6446(20011015)6:20<1049:CMAAES>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; HMG-COA REDUCTASE; APOLIPOPROTEIN-E; BETA-PROTEIN; A-BETA; DEPENDENT GENERATION; MOUSE MODEL; PEPTIDE; DEPOSITION; BRAIN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Golde, TE Mayo Clin Jacksonville, Dept Neurosci, 4500 San Pablo Rd, Jacksonville, FL32224 USA Mayo Clin Jacksonville 4500 San Pablo Rd Jacksonville FL USA 32224
Citazione:
T.E. Golde e C.B. Eckman, "Cholesterol modulation as an emerging strategy for the treatment of Alzheimer's disease", DRUG DISC T, 6(20), 2001, pp. 1049-1055

Abstract

The basis for therapeutic strategies targeting the amyloid-P protein (A beta) has come from studies showing that accumulation and aggregation of the A beta within the brain is likely to cause Alzheimer's disease (A beta). Along with an ever-increasing understanding of A beta metabolism, many potential therapeutic strategies aimed at altering A beta metabolism have emerged. Among the more intriguing targets for therapy are enzymes involved in cholesterol homeostasis, because it has been found that altering cholesterol can influence A beta metabolism in experimental model systems, and that cholesterol-lowering agents, specifically HMG-CoA reductase inhibitors, could reduce the incidence of A beta. It is likely that cholesterol influences A beta metabolism in several ways, including altering A beta production and perhaps altering A beta deposition and clearance. Thus, pharmacological modulation of cholesterol levels could provide a relatively safe means to reduceA beta accumulation in the brain, and thereby prevent or slow the development of A beta.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 06:35:06