Catalogo Articoli (Spogli Riviste)

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Titolo:
Does the presence of distant and local malignancy alter parenchymal perfusion in apparently disease-free areas of the liver?
Autore:
Tsushima, Y; Blomley, MJK; Yokoyama, H; Kusano, S; Endo, K;
Indirizzi:
Gunma Univ Hosp, Dept Diagnost Radiol & Nucl Med, Maebashi, Gumma 3718511,Japan Gunma Univ Hosp Maebashi Gumma Japan 3718511 aebashi, Gumma 3718511,Japan Univ London Imperial Coll Sci Technol & Med, Sch Med, London W12 OHS, England Univ London Imperial Coll Sci Technol & Med London England W12 OHS gland Hammersmith Hosp, Dept Imaging, London W12 OHS, England Hammersmith Hosp London England W12 OHS Imaging, London W12 OHS, England Natl Def Med Coll, Dept Radiol, Tokorozawa, Saitama 3590042, Japan Natl Def Med Coll Tokorozawa Saitama Japan 3590042 Saitama 3590042, Japan
Titolo Testata:
DIGESTIVE DISEASES AND SCIENCES
fascicolo: 10, volume: 46, anno: 2001,
pagine: 2113 - 2119
SICI:
0163-2116(200110)46:10<2113:DTPODA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
DYNAMIC COMPUTED-TOMOGRAPHY; COLOR DOPPLER SONOGRAPHY; PHASE HELICAL CT; HEPATIC METASTASES; BLOOD-FLOW; CANCER; INDEX; ENHANCEMENT; SCINTIGRAPHY; DIFFERENCE;
Keywords:
liver; metastasis; hemodynamics; dynamic computed tomography; perfusion measurement;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Tsushima, Y Motojima Gen Hosp, Dept Radiol, 3-8 Nishi Honcho, Ohta, Gunma 3730033, Japan Motojima Gen Hosp 3-8 Nishi Honcho Ohta Gunma Japan 3730033 an
Citazione:
Y. Tsushima et al., "Does the presence of distant and local malignancy alter parenchymal perfusion in apparently disease-free areas of the liver?", DIG DIS SCI, 46(10), 2001, pp. 2113-2119

Abstract

Our objective was to investigate if hepatic arterial (HAP) and portal venous perfusion (PVP) in apparently normal areas of liver, as measured by functional CT, are affected by the presence of extra- and intrahepatic malignancy Three patient groups were compared: A, controls with no malignancy (N = 10); B, extrahepatic malignancy without liver involvement (N = 12); and C, subjects with metastases elsewhere in the liver (N = 13). HAP, PVP, and a CT hepatic perfusion index (CT-HPI) calculated as HAP/(HAP + PVP) were calculated on a section free of metastatic disease, using a previously publishedmethod. Figures for PVP were (median and interquartile range) in group A were 1.06 (0.9-1.30). in B 1.03 (0.81-1.09), and in C 0.75 (0.54-1.02) ml/min/ml; for HAP group A values were 0.07 (0.052-0.078), in B 0.07 (0.053-0.147), and in C 0.12 (0.091-0.146) ml/min/ml and for CT-HPI Group A values were 4.9% (4.8-6.6%), in B 5.6% (3.8-13.6%), and in C 14.3% (10.4-15.4%). Significant differences in all indices were seen between groups A and C. A significant difference (P = 0.017) was seen between groups B and C in the CT-HPI values. In conclusion, patients with liver metastases show abnormal bloodflow in apparently normal liver compared to controls. This difference was not seen in subjects with malignancy without liver metastases. Possible explanations would be either the unmasking of occult metastatic disease or vasoactive or mechanical effects due to liver malignancy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:54:21