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Titolo:
Pericentral hepatocytes translocate hydrophilic bile acids more rapidly than hydrophobic ones
Autore:
Baumgartner, U; Baier, P; Mappes, HJ; Farthmann, EH;
Indirizzi:
Univ Freiburg, Dept Surg, D-79106 Freiburg, Germany Univ Freiburg Freiburg Germany D-79106 t Surg, D-79106 Freiburg, Germany
Titolo Testata:
DIGESTIVE DISEASES AND SCIENCES
fascicolo: 10, volume: 46, anno: 2001,
pagine: 2098 - 2103
SICI:
0163-2116(200110)46:10<2098:PHTHBA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
SALT EXPORT PUMP; RAT-LIVER; CANALICULAR MEMBRANE; TRANSPORT; HETEROGENEITY; LOCALIZATION; SYSTEM; CELLS;
Keywords:
bile acids; bile acid transport; liver heterogeneity; metabolic zonation; liver perfusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Baumgartner, U Univ Freiburg, Dept Surg, Hugstetter Str 55, D-79106 Freiburg, Germany Univ Freiburg Hugstetter Str 55 Freiburg Germany D-79106 y
Citazione:
U. Baumgartner et al., "Pericentral hepatocytes translocate hydrophilic bile acids more rapidly than hydrophobic ones", DIG DIS SCI, 46(10), 2001, pp. 2098-2103

Abstract

The aim of this study was to analyze whether velocity of periportal and pericentral translocation is different for bile acids differing in their physicochemical properties. Isolated livers of male Sprague-Dawley rats were perfused antegradely or retrogradely, in single pass arrangement with labeledtaurodehydrocholate, cholate, taurocholate, glycocholate, or taurodeoxycholate (inflow rate: 32 nmol/min/g liver). Bile was collected at 2-min intervals; aliquots were counted in a liquid scintillation spectrophotometer to trace uptake rate and biliary excretion profile. Biliary excretion patterns of all bile acids tested were almost identical in periportal cells; in contrast, it differed greatly in pericentral cells. Pericentral cells excreted taurodehydrocholate as fast as periportal cells, while periportal cells eliminated taurodeoxycholate about four times as fast and cholate, taurocholate and cholate about two times as fast as pericentral cells. It is concludedthat, in contrast to periportal translocation, the velocity of pericentraltranslocation depends upon the hydrophilicity of the respective bile acid. Therefore, different or additional translocation pathways for bile acids may be involved in periportal versus pericentral cells.

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Documento generato il 04/07/20 alle ore 05:17:43