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Titolo:
Alopecia areata and affected skin CRH receptor upregulation induced by acute emotional stress
Autore:
Katsarou-Katsari, A; Singh, LK; Theoharides, TC;
Indirizzi:
Tufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02111 USATufts Univ Boston MA USA 02111 col & Expt Therapeut, Boston, MA 02111 USA Univ Athens, Sch Med, A Syggros Hosp Dermatol Dis, GR-11527 Athens, GreeceUniv Athens Athens Greece GR-11527 Dermatol Dis, GR-11527 Athens, Greece
Titolo Testata:
DERMATOLOGY
fascicolo: 2, volume: 203, anno: 2001,
pagine: 157 - 161
SICI:
1018-8665(2001)203:2<157:AAAASC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; MAST-CELL DEGRANULATION; MALE PATTERN ALOPECIA; VASCULAR-PERMEABILITY; IMMUNE-SYSTEM; MURINE SKIN; SUBSTANCE-P; HAIR CYCLE; INVOLVEMENT; DISEASE;
Keywords:
alopecia; corticotropin-releasing hormone; mast cells; inflammation; stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Theoharides, TC Tufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, 136 Harrison Ave, Boston, MA 02111 USA Tufts Univ 136 Harrison Ave Boston MA USA 02111 02111 USA
Citazione:
A. Katsarou-Katsari et al., "Alopecia areata and affected skin CRH receptor upregulation induced by acute emotional stress", DERMATOLOGY, 203(2), 2001, pp. 157-161

Abstract

Background. Recent evidence indicates that acute stress can precipitate a number of dermatological conditions, including alopecia areata. This effectmay be mediated by corticotropin-releasing hormone (CRH) released locally in the skin from dorsal root ganglia or immune cells. CRH typically acts through activation of specific receptors that are either type 1 or types 2 alpha and 2 beta. CRH, or related peptides such as urocortin, could have proinflammatory effects directly or through activation of mast cells leading todestruction of the hair root. Objectives: To investigate the expression ofCRH receptors on the affected skin of patients who developed alopecia areata following acute emotional stress. Methods: Scalp skin biopsies were obtained from 1 normal volunteer and 3 patients after ring infiltration of the relevant site with lidocaine. The biopsies were frozen and were later processed for in situ hybridization for CRH receptors type 1 or types 2 alpha and 2 beta. Sections showing positive results were photographed. Results: Theskin from the normal volunteer showed weak background expression of all three receptor types. However, skin from the affected sites of all 3 patientsstudied showed intense expression only on the type 2 beta receptor around the hair follicles. Conclusion: Acute emotional stress may precipitate alopecia areata by activation of overexpressed type 2 beta CRH receptors aroundthe hair follicles leading to intense local inflammation. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:23:27