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Titolo:
Retargeting gene delivery using surface-engineered retroviral vector particles
Autore:
Lavillette, D; Russell, SJ; Cosset, FL;
Indirizzi:
Ecole Normale Super Lyon, INSERM U412, Unite Virol Humaine, Lab Vectorol Retrovirale & Therapie Genique, F-69364 Lyon 07, France Ecole Normale Super Lyon Lyon France 07 Genique, F-69364 Lyon 07, France Mayo Clin & Mayo Fdn, Program Mol Med, Rochester, MN 55905 USA Mayo Clin &Mayo Fdn Rochester MN USA 55905 Med, Rochester, MN 55905 USA
Titolo Testata:
CURRENT OPINION IN BIOTECHNOLOGY
fascicolo: 5, volume: 12, anno: 2001,
pagine: 461 - 466
SICI:
0958-1669(200110)12:5<461:RGDUSR>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SINGLE-CHAIN ANTIBODIES; LEUKEMIA-VIRUS ENTRY; RECEPTOR-BINDING; INFLUENZA HEMAGGLUTININ; ENVELOPE GLYCOPROTEIN; MEMBRANE-FUSION; MELANOMA-CELLS; PROTEIN; DISPLAY; DOMAIN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Lavillette, D Ecole Normale Super Lyon, INSERM U412, Unite Virol Humaine, Lab Vectorol Retrovirale & Therapie Genique, 46 Allee Italie, F-69364 Lyon 07, France Ecole Normale Super Lyon 46 Allee Italie Lyon France 07 nce
Citazione:
D. Lavillette et al., "Retargeting gene delivery using surface-engineered retroviral vector particles", CURR OPIN B, 12(5), 2001, pp. 461-466

Abstract

Retroviral vectors with the capacity to deliver transgenes to specific tissues are expected to be of great value for various gene transfer applications in vivo. Initial attempts to modify vector host-range by the insertion of ligands on their surface glycoproteins have frequently failed, essentially owing to the impairment of the fusogenicity of the vector particles boundto the targeted cell-surface molecules. Several strategies aimed to recover the fusogenic activity of surface-engineered vector particles have recently been explored and have given rise to novel concepts in the field.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:18:12