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Titolo:
Human immunodeficiency virus-seronegative adults with extrapulmonary tuberculosis have abnormal innate immune responses
Autore:
Sterling, TR; Dorman, SE; Chaisson, RE; Ding, L; Hackman, J; Moore, K; Holland, SM;
Indirizzi:
Johns Hopkins Univ, Sch Med, Div Infect Dis, Baltimore, MD 21205 USA JohnsHopkins Univ Baltimore MD USA 21205 ct Dis, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USAJohns Hopkins Univ Baltimore MD USA 21205 demiol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Publ Hlth, Dept Int Hlth, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 t Hlth, Baltimore, MD 21205 USA Baltimore City Hlth Dept Eastern Chest Clin, Baltimore, MD USA Baltimore City Hlth Dept Eastern Chest Clin Baltimore MD USA ore, MD USA NIAID, NIH, Lab Host Def, Bethesda, MD USA NIAID Bethesda MD USANIAID, NIH, Lab Host Def, Bethesda, MD USA
Titolo Testata:
CLINICAL INFECTIOUS DISEASES
fascicolo: 7, volume: 33, anno: 2001,
pagine: 976 - 982
SICI:
1058-4838(20011001)33:7<976:HIVAWE>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; INTERFERON-GAMMA PRODUCTION; TOLL-LIKE RECEPTORS; CD4 CELL COUNTS; MYCOBACTERIUM-TUBERCULOSIS; FACTOR-ALPHA; PULMONARY TUBERCULOSIS; INFECTION; INTERLEUKIN-12; MACROPHAGES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Sterling, TR Ctr TB Res, 424 N Bond St, Baltimore, MD 21231 USA Ctr TB Res424 N Bond St Baltimore MD USA 21231 MD 21231 USA
Citazione:
T.R. Sterling et al., "Human immunodeficiency virus-seronegative adults with extrapulmonary tuberculosis have abnormal innate immune responses", CLIN INF D, 33(7), 2001, pp. 976-982

Abstract

Extrapulmonary tuberculosis is presumably a marker of underlying immunodeficiency, but cytokine response pathways in these patients have not been well studied. Cytokine responses of peripheral blood mononuclear cells from human immunodeficiency virus-seronegative adults with prior culture-confirmedextrapulmonary tuberculosis were compared with those of persons with latent Mycobacterium tuberculosis infection. Mitogen-stimulated interferon (IFN)-gamma production, interleukin (IL)-12 production, and -gamma receptor- andIL-12 receptor-mediated cytokine production did not differ between case patients and control patients. However, median resting IL-8 production was significantly lower in case patients than control patients (8051 vs. 19,290 pg/mL; P=.009). In addition, the median tumor necrosis factor (TNF)-alpha response was lower in case patients than control patients after stimulation with lipopolysaccharide (833 vs. 1149 pg/mL; P=.06) and lipopolysaccharide plus IFN-gamma (3301 vs. 4411 pg/mL; P=.04). These abnormalities in resting IL-8 and lipopolysaccharide-induced TNF-alpha production were not associated with IFN-gamma or IL-12 abnormalities and were detected up to several years after cure of disease, suggesting an abnormality in innate immunity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:03:54