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Titolo:
Hyperhomocysteinaemia and human reproduction
Autore:
Nelen, WLDM;
Indirizzi:
Univ Med Ctr St Radboud, Dept Obstet & Gynaecol, NL-6500 HB Nijmegen, Netherlands Univ Med Ctr St Radboud Nijmegen Netherlands NL-6500 HB gen, Netherlands
Titolo Testata:
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
fascicolo: 8, volume: 39, anno: 2001,
pagine: 758 - 763
SICI:
1434-6621(200108)39:8<758:HAHR>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURAL-TUBE DEFECTS; EARLY-PREGNANCY LOSS; 5,10-METHYLENETETRAHYDROFOLATE REDUCTASE GENE; BETA-SYNTHASE DEFICIENCY; METHYLENETETRAHYDROFOLATE REDUCTASE; RISK FACTOR; PLASMA HOMOCYSTEINE; VASCULAR-DISEASE; COMMON MUTATION; MATERNAL HYPERHOMOCYSTEINEMIA;
Keywords:
homocysteine; MTHFR; pregnancy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Nelen, WLDM Univ Med Ctr St Radboud, Dept Obstet & Gynaecol, POB 9101, NL-6500 HB Nijmegen, Netherlands Univ Med Ctr St Radboud POB 9101 Nijmegen Netherlands NL-6500 HB
Citazione:
W.L.D.M. Nelen, "Hyperhomocysteinaemia and human reproduction", CLIN CH L M, 39(8), 2001, pp. 758-763

Abstract

Mild hyperhomocysteinaemia has been identified as a risk factor for arterial disease and venous thrombosis. In 1991, elevated homocysteine concentrations were also suggested to be associated with neural tube defects (NTD). Since then this relationship has been reported frequently, as well as the relationship between NTD and the 677 C -->T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene. Meanwhile, disturbances in the homocysteine metabolism have also been reported as a risk factor for early pregnancy loss and for other congenital birth defects. However, besides embryonic or foetal consequences, hyperhomocysteinaemia has also been described as a cause of maternal obstetric complications such as pre-eclampsia. This review isconcerned with the role of hyperhomocysteinaemia in human reproduction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 03:42:35