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Titolo:
Homocysteine, vascular dementia and Alzheimer's disease
Autore:
Joosten, E;
Indirizzi:
Univ Hosp KU Leuven, Dept Internal Med, Div Geriatr Med, B-3000 Louvain, Belgium Univ Hosp KU Leuven Louvain Belgium B-3000 Med, B-3000 Louvain, Belgium
Titolo Testata:
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
fascicolo: 8, volume: 39, anno: 2001,
pagine: 717 - 720
SICI:
1434-6621(200108)39:8<717:HVDAAD>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PSYCHOGERIATRIC POPULATION; VITAMIN-B12 DEFICIENCY; COBALAMIN DEFICIENCY; PLASMA HOMOCYSTEINE; METABOLIC EVIDENCE; FOLATE-DEFICIENCY; SERUM; REPLACEMENT; PERFORMANCE; DISORDERS;
Keywords:
Alzheimer's disease; vascular dementia; homocysteine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Joosten, E Univ Hosp KU Leuven, Dept Internal Med, Div Geriatr Med, Brusselsestr 69, B-3000 Louvain, Belgium Univ Hosp KU Leuven Brusselsestr 69 Louvain Belgium B-3000 ium
Citazione:
E. Joosten, "Homocysteine, vascular dementia and Alzheimer's disease", CLIN CH L M, 39(8), 2001, pp. 717-720

Abstract

There is some evidence from recent observational studies that hyperhomocysteinemia is a risk factor for cognitive dysfunction, including Alzheimer's disease and vascular dementia. There are only a few intervention studies, and the results are disappointing for such a frequent disease. Prospective double-blind and placebo-controlled intervention studies are not available. If homocysteine-lowering therapy will be in the running for the prevention and treatment of dementia, we must be able to diagnose the disease at a preclinical stage (i.e. 5 or 10 or 20 years before the disease becomes clinically overt for Alzheimer's disease). At the moment, there are insufficient data to support a vitamin B-12, B-6 or folate therapy in the prevention or treatment of patients with dementia.

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Documento generato il 06/04/20 alle ore 01:53:35