Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Heterogeneity of the association between plasma homocysteine and atherothrombotic disease: Insights from studies of vascular structure and function
Autore:
Stehouwer, CDA;
Indirizzi:
Vrije Univ Amsterdam, Med Ctr, Inst Cardiovasc Res, Dept Med, NL-1081 HV Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands NL-1081 HV erdam, Netherlands
Titolo Testata:
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
fascicolo: 8, volume: 39, anno: 2001,
pagine: 705 - 709
SICI:
1434-6621(200108)39:8<705:HOTABP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT VASODILATATION; METHIONINE-INDUCED HYPERHOMOCYSTEINEMIA; VITAMIN-TREATED HYPERHOMOCYSTEINAEMIA; PERITONEAL-DIALYSIS PATIENTS; ARTERIAL OCCLUSIVE DISEASE; PLACEBO-CONTROLLED TRIAL; CORONARY HEART-DISEASE; VON-WILLEBRAND-FACTOR; FOLIC-ACID; SERUM HOMOCYSTEINE;
Keywords:
homocysteine; folic acid; atherothrombosis; arterial stiffness; endothelium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Stehouwer, CDA Vrije Univ Amsterdam, Med Ctr, Inst Cardiovasc Res, Dept Med, De Boelelaan1117, NL-1081 HV Amsterdam, Netherlands Vrije Univ AmsterdamDe Boelelaan 1117 Amsterdam Netherlands NL-1081 HV
Citazione:
C.D.A. Stehouwer, "Heterogeneity of the association between plasma homocysteine and atherothrombotic disease: Insights from studies of vascular structure and function", CLIN CH L M, 39(8), 2001, pp. 705-709

Abstract

Among individuals with severe hyperhomocysteinaemia, there is a striking heterogeneity in the severity of the clinical features. This observation demonstrates that factors must exist that modulate the relationship between hyperhomocysteinaemia and clinical disease. Investigations of the associationbetween mild-to-moderate hyperhomocysteinaemia and atherothrombotic disease also suggest heterogeneity in the association between plasma homocysteinelevels and 1) clinical disease; 2) angiographic and echographic estimates of the extent of atherosclerosis; 3) arterial stiffness; 4) endothelial function; and 5) procoagulant status. The commonly held view that homocysteineis a vasculotoxic substance that promotes atherogenesis by causing endothelial damage is incomplete, because it cannot explain this heterogeneity. I suggest that homocysteine may have both prothrombotic and proatherogenic properties, but that there are strong, as yet unidentified enhancing and protective factors, the prevalence of which may differ among populations. This concept could account for some of the observed heterogeneity. Identifying these factors would be of major clinical importance and would provide crucial mechanistic insights.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 13:55:39