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Titolo:
Influence of the IL-1Ra gene polymorphism on in vivo synthesis of IL-1Ra and IL-1 beta after live yellow fever vaccination
Autore:
Hacker, UT; Erhardt, S; Tschop, K; Jelinek, T; Endres, S;
Indirizzi:
Univ Munich, Univ Hosp, Div Clin Pharmacol, D-80336 Munich, Germany Univ Munich Munich Germany D-80336 in Pharmacol, D-80336 Munich, Germany Univ Munich, Univ Hosp, Dept Med 3, D-80336 Munich, Germany Univ Munich Munich Germany D-80336 , Dept Med 3, D-80336 Munich, Germany Univ Munich, Univ Hosp, Dept Anaesthesiol, D-80336 Munich, Germany Univ Munich Munich Germany D-80336 Anaesthesiol, D-80336 Munich, Germany Univ Munich, Univ Hosp, Div Trop Med & Infect Dis, D-80336 Munich, GermanyUniv Munich Munich Germany D-80336 & Infect Dis, D-80336 Munich, Germany
Titolo Testata:
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
fascicolo: 3, volume: 125, anno: 2001,
pagine: 465 - 469
SICI:
0009-9104(200109)125:3<465:IOTIGP>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERLEUKIN-1 RECEPTOR ANTAGONIST; ULCERATIVE-COLITIS; ASSOCIATION; ALLELE; DISEASE;
Keywords:
cytokine; interleukin 1-receptor antagonist; yellow fever;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Endres, S Univ Munich, Univ Hosp, Div Clin Pharmacol, Ziemssenstr 1, D-80336 Munich,Germany Univ Munich Ziemssenstr 1 Munich Germany D-80336 Munich,Germany
Citazione:
U.T. Hacker et al., "Influence of the IL-1Ra gene polymorphism on in vivo synthesis of IL-1Ra and IL-1 beta after live yellow fever vaccination", CLIN EXP IM, 125(3), 2001, pp. 465-469

Abstract

The inflammatory response in infectious and autoimmune diseases is regulated by the balance between pro- and anti-inflammatory cytokines. The IL-1 complex contains polymorphic genes coding for IL-1 alpha, IL-1 beta and IL-1Ra. The IL-1Ra (variable number of tanden repeat) VNTR polymorphism has beenshown to influence the capacity to produce IL-1 beta and IL-1Ra after in vitro stimulation. Allele 2 of this polymorphism is associated with a numberof inflammatory diseases. To determine the impact of the IL-1Ra polymorphism on in vivo human cytokine synthesis, we used a yellow fever vaccination model for the induction of cytokine synthesis in healthy volunteers. Two different yellow fever vaccines were used. After administration of the RKI vaccine (34 volunteers), plasma TNF-alpha concentration increased from 13.4 +/- 0.9 pg/ml to 23.3 +/- 1.1 pg/ml (P < 0.001), and plasma IL-1Ra concentration increased from 308 +/- 25 pg/ml to 1019 +/- 111 pg/ml (P < 0.001), on day 2. Using Stamaril (R) vaccine, no increase in the plasma concentrationsof either TNF-alpha or IL-1Ra could be detected (n = 17). Only the RKI vaccine induced TNF-alpha synthesis after in vitro stimulation of MNC. Carriers of allele 2 of the IL-1Ra polymorphism had increased baseline concentrations of IL-1Ra (350 +/- 32 pg/ml) compared with non-carriers (222 +/- 18 pg/ml, P < 0.001), and decreased concentrations of IL-1 beta (0.9 +/- 0.2 pg/ml for carriers versus 2.8 +/- 0.7 pg/ml for non-carriers, P = 0.017). Afteryellow fever vaccination (RKI vaccine), no significant differences in the increase of IL-1Ra plasma levels were detected between carriers and non-carriers of allele 2 of the IL-1Ra gene polymorphism. This is the first study to examine the influence of this genetic polymorphism on in vivo-induced human IL-1 beta and IL-1Ra synthesis. Baseline concentrations of IL-1Ra and IL-1 beta were significantly influenced by the IL-1Ra polymorphism. No influence of the IL-1Ra polymorphism on the in vivo-induced production of IL-1Raand IL-1 beta could be detected.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:08:08