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Titolo:
Day-night variations in blood levels of nitric oxide, T-TFPI, and E-selectin
Autore:
Kanabrocki, EL; George, M; Hermida, RC; Messmore, HL; Ryan, MD; Ayala, DE; Hoppensteadt, DA; Fareed, J; Bremner, FW; Third, JLHC; Shirazi, P; Nemchausky, BA;
Indirizzi:
Vet Affairs Med Ctr, Nucl Med Serv, Hines, IL 60141 USA Vet Affairs Med Ctr Hines IL USA 60141 Nucl Med Serv, Hines, IL 60141 USA Vet Affairs Med Ctr, Res Serv, Hines, IL 60141 USA Vet Affairs Med Ctr Hines IL USA 60141 Ctr, Res Serv, Hines, IL 60141 USA Vet Affairs Med Ctr, Serv Cardiol, Hines, IL 60141 USA Vet Affairs Med Ctr Hines IL USA 60141 Serv Cardiol, Hines, IL 60141 USA Vet Affairs Med Ctr, Spinal Cord Injury Serv, Hines, IL 60141 USA Vet Affairs Med Ctr Hines IL USA 60141 d Injury Serv, Hines, IL 60141 USA Loyola Univ, Med Ctr, Dept Pathol, Maywood, IL 60153 USA Loyola Univ Maywood IL USA 60153 Ctr, Dept Pathol, Maywood, IL 60153 USA Loyola Univ, Med Ctr, Dept Pharmacol, Maywood, IL 60153 USA Loyola Univ Maywood IL USA 60153 r, Dept Pharmacol, Maywood, IL 60153 USA Univ Vigo, Bioengn & Chronobiol Labs, Vigo, Spain Univ Vigo Vigo SpainUniv Vigo, Bioengn & Chronobiol Labs, Vigo, Spain MacNeal Cardiol Grp, Berwyn, IL USA MacNeal Cardiol Grp Berwyn IL USAMacNeal Cardiol Grp, Berwyn, IL USA
Titolo Testata:
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
fascicolo: 4, volume: 7, anno: 2001,
pagine: 339 - 345
SICI:
1076-0296(200110)7:4<339:DVIBLO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRINSIC PATHWAY INHIBITOR; COAGULATION INHIBITOR; URIC-ACID; ALZHEIMERS-DISEASE; HUMAN-PLASMA; TIME-SERIES; PEROXYNITRITE; PURIFICATION; SYNTHASE;
Keywords:
circadian; NO; E-selectin; T-TFPI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Kanabrocki, EL Vet Affairs Med Ctr, Nucl Med Serv 115, Hines, IL 60141 USAVet Affairs Med Ctr Hines IL USA 60141 Hines, IL 60141 USA
Citazione:
E.L. Kanabrocki et al., "Day-night variations in blood levels of nitric oxide, T-TFPI, and E-selectin", CL APPL T-H, 7(4), 2001, pp. 339-345

Abstract

Circadian (8/24 hours) variations in serum nitric oxide (NO). total tissuefactor pathway inhibitor (T-TFPI), and E-selectin levels were studied in healthy adults and in subjects with type II diabetes. We postulated a possibility a functional relationship between them because vascular endothelium is the primary site of their synthesis and functions. NO is released by the action of eNO synthase isoform and modulates physiologic responses (e.g., vascular dilation, relaxation, increasing blood flow, inhibition of plateletand white blood cell adhesion); T-TFPI, a coagulation inhibitor, is also released from endothelial cells, and is bound to plasma lipoproteins and to glycosaminoglycans; E-selectin is expressed on endothelial cells after activation by inflammatory cytokines (interleukin-1 beta and tumor necrosis factor-alpha) and elevated levels have been reported in a variety of pathologic conditions, including diabetes, We found that obese diabetic subjects hadgreater mean concentrations of NO and E-selectin than healthy men, 39.25 versus 12.71 muM and 81.51 versus 26.03 ng/mL, respectively. The T-TFPI levels were essentially similar in both groups of men. 47.10 versus 48.76 ng/mL. We observed that the time of peak concentrations of T-TFPI and E-selectinwas similar to the timing of NO trough levels, suggesting a possible functional relationship. It may be hypothesized. therefore, that the higher concentrations of NO, unbalanced by increases in T-TFPI and E-selectin, may result in increased vascular wall uptake of lipoproteins in diabetic subjects,who are at greater risk than healthy men for developing diffuse atherosclerosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 03:20:58