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Titolo:
Plasma fibrinogen level is an important determinant of prolonged euglobulin clot lysis time in hemodialysis patients
Autore:
Borawski, J; Mysliwiec, M;
Indirizzi:
Med Acad Bialystok, Dept Nephrol & Internal Med, PL-15540 Bialystok, Poland Med Acad Bialystok Bialystok Poland PL-15540 PL-15540 Bialystok, Poland
Titolo Testata:
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
fascicolo: 4, volume: 7, anno: 2001,
pagine: 296 - 299
SICI:
1076-0296(200110)7:4<296:PFLIAI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATELET-FUNCTION; ERYTHROPOIETIN; HEMOSTASIS; SEROTONIN; FAILURE;
Keywords:
euglobulin clot lysis time; fibrinogen; hemodialysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Borawski, J Med Acad Bialystok, Dept Nephrol & Internal Med, 14 Zurawia St, PL-15540 Bialystok, Poland Med Acad Bialystok 14 Zurawia St Bialystok Poland PL-15540 nd
Citazione:
J. Borawski e M. Mysliwiec, "Plasma fibrinogen level is an important determinant of prolonged euglobulin clot lysis time in hemodialysis patients", CL APPL T-H, 7(4), 2001, pp. 296-299

Abstract

The euglobulin clot lysis time (ECLT), a traditional measure of plasminogen activation. directly depends on plasma fibrinogen (FBG) level. This fact was neglected in studies concluding that prolonged ECLT in chronic hemodialysis (HD) patients pointed exclusively to impaired fibrinolysis. We studiedthe relations between ECLT and plasma FBG levels in HD patients in relation to certain hepatic and inflammatory markers. Median ECLT of 320 minutes (range, 150 to 620 minutes) and plasma FBG of 306 mg/dL (range, 171 to 553 mg/dL) were higher in 75 HD patients than in 60 healthy controls (Mann-Whitney p < 0.0001). There were positive associations between these parameters both in the patients (Spearman p = 0.273, p = 0.018) and the controls (p = 0.672, p < 0.0001). The FBG-corrected ECLT (plasma FBG/ECLT) (in mg/[min x dL]) in the patients (0.92 [range, 0.47 to 2.43]) was not different (p = 0.065) from that in the controls (1.08 [0.58 to 1.67]). In the patients, serumalanine aminotransferase inversely correlated with ECLT (p = -0.306, p = 0.008) and FBG (p = -0.310, p = 0.007), whereas serum C-reactive protein wasassociated positively with these variables (p = 0.383, p = 0.0007; p = 0.477, p < 0.0001, respectively). The FBG-corrected ECLT was not related to either marker. In conclusion, increased plasma FBG level, a continuum betweenliver dysfunction and stimulation by chronic inflammation, is an importantdeterminant of prolonged ECLT in HD patients. The FBG-corrected ECLT valuesuggests that baseline activation of fibrinolysis is normal in these patients, and that this simple index could be useful in its laboratory assessment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 13:10:10