Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Intraoperative photodynamic therapy after pleuropneumonectomy in patients with malignant pleural mesothelioma - Dose finding and toxicity results
Autore:
Schouwink, H; Rutgers, ET; van der Sijp, J; Oppelaar, H; van Zandwijk, N; van Veen, R; Burgers, S; Stewart, FA; Zoetmulder, F; Baas, P;
Indirizzi:
Netherlands Canc Inst, Dept Thorac Oncol, NL-1066 CX Amsterdam, Netherlands Netherlands Canc Inst Amsterdam Netherlands NL-1066 CX rdam, Netherlands Netherlands Canc Inst, Dept Surg Oncol, NL-1066 CX Amsterdam, Netherlands Netherlands Canc Inst Amsterdam Netherlands NL-1066 CX rdam, Netherlands Netherlands Canc Inst, Dept Expt Therapy, NL-1066 CX Amsterdam, Netherlands Netherlands Canc Inst Amsterdam Netherlands NL-1066 CX rdam, Netherlands Univ Hosp Rotterdam Daniel, Dept Thorac Oncol, Rotterdam, Netherlands UnivHosp Rotterdam Daniel Rotterdam Netherlands Rotterdam, Netherlands Univ Hosp Rotterdam Daniel, Dept Surg Oncol, Rotterdam, Netherlands Univ Hosp Rotterdam Daniel Rotterdam Netherlands Rotterdam, Netherlands Univ Hosp Rotterdam Daniel, Dept Clin Phys, Rotterdam, Netherlands Univ Hosp Rotterdam Daniel Rotterdam Netherlands Rotterdam, Netherlands
Titolo Testata:
CHEST
fascicolo: 4, volume: 120, anno: 2001,
pagine: 1167 - 1174
SICI:
0012-3692(200110)120:4<1167:IPTAPI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHASE-II TRIAL; MULTIMODALITY THERAPY; IMMUNOCHEMOTHERAPY; CHEMOTHERAPY; TOMOGRAPHY; METASTASES; OPERATION; CT;
Keywords:
extrapleural pneumonectomy; light dosimetry; malignant pleural mesothelioma; meta-tetrahydroxyphenylchlorin; photodynamic therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Baas, P Netherlands Canc Inst, Dept Thorac Oncol, Plesmanlaan 121, NL-1066CX Amsterdam, Netherlands Netherlands Canc Inst Plesmanlaan 121 AmsterdamNetherlands NL-1066 CX
Citazione:
H. Schouwink et al., "Intraoperative photodynamic therapy after pleuropneumonectomy in patients with malignant pleural mesothelioma - Dose finding and toxicity results", CHEST, 120(4), 2001, pp. 1167-1174

Abstract

Objective: To determine the optimal administered dose of meta-tetrahydroxyphenylchlorin (mTHPC) for intraoperative photodynamic therapy (IPDT) in resected malignant pleural mesothelioma (MPM). The primary objective of this combination treatment was to improve local tumor control. Design: Phase I/II close escalation study. Setting: Two Dutch cancer centers. Patients: The study included 28 patients (2 women, 26 men), with pathologically confirmed MPM. The mean age was 57 Scars (age range, 37 to 68 years),and the World Health Organization performance score was 0 to 1. Epithelialmesotheliomas were found in 17 patients, a sarcomatous mesothelioma was found in 1 patient, and mixed epithelial sarcomatous mesotheliomas were foundin 10 patients. Methods: Patients were injected with 0.075 mg/kg (4 patients), 0.10 mg/kg (19 patients), or 0.15 mg/kg (5 patients) mTHPC 4 or 6 days before undergoing surgery and IPDT. Complete surgical resection (re, pleuropneumonectomy) was followed by integral illumination with monochromatic light of 652 nm (10 J/cm(2)). The real-time fluence rate measurements were performed using four isotropic detectors in the chest cavity to calculate the total light dose. Results: Dose-limiting toxicity was reached at die level of 0.15 mg/kg mTHPC. Three patients died in the perioperative period, and one death was directly related to photodynamic therapy. Real-time dosimetry identified 12 patients in whom additional illumination had to be given to the diaphragmatic sinuses, which were unavoidably shielded during integral illumination. In two patients, illumination was cancelled clue to the insufficient resectability of the tumor. The median survival time for all 28 patients was 10 months. Local tumor control, 9 months after treatment, was achieved in 13 of the26 patients treated with IPDT. Conclusion: IPDT using mTHPC, combined with a pleuropneumonectomy, resulted in local control of disease in 50% of the treated cases. The considerabletoxicity associated with die procedure, however, precludes its recommendation for widespread use. Stricter patient selection and improvements of the IPDT technique may, reduce the toxicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 08:57:00