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Titolo:
Differential cell counts in sputum in respiratory epidemiology - A pilot study
Autore:
Lemiere, C; Walker, C; OShaughnessy, D; Efthimiadis, A; Hargreave, FE; Sears, MR;
Indirizzi:
McMaster Univ, St Josephs Healthcare, Firestone Reg Inst Resp Hlth, Dept Med,Asthma Res Grp, Hamilton, ON L8N 4A6, Canada McMaster Univ Hamilton ON Canada L8N 4A6 rp, Hamilton, ON L8N 4A6, Canada
Titolo Testata:
CHEST
fascicolo: 4, volume: 120, anno: 2001,
pagine: 1107 - 1113
SICI:
0012-3692(200110)120:4<1107:DCCISI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
AIRWAY INFLAMMATION; BRONCHIAL RESPONSIVENESS; ASTHMA; SYMPTOMS; EOSINOPHILS; HYPERRESPONSIVENESS; HYPERREACTIVITY; EXACERBATIONS; METHACHOLINE; INDEXES;
Keywords:
airway hyperresponsiveness; asthma; eosinophils; epidemiology; induced sputum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Sears, MR McMaster Univ, St Josephs Healthcare, Firestone Reg Inst Resp Hlth, Dept Med,Asthma Res Grp, 50 Charlton Ave E, Hamilton, ON L8N 4A6, Canada McMaster Univ 50 Charlton Ave E Hamilton ON Canada L8N 4A6 anada
Citazione:
C. Lemiere et al., "Differential cell counts in sputum in respiratory epidemiology - A pilot study", CHEST, 120(4), 2001, pp. 1107-1113

Abstract

Background: The aim of this pilot study was to determine whether measuringsputum differential cell counts, particularly eosinophils, could be a useful method of validating self-reported symptoms suggesting asthma in epidemiologic studies. Materials and methods: In this cross-sectional study, we selected four groups of adult subjects by reported symptoms and diagnoses from among those previously randomly identified in a population study. Subjects were selectedwith no respiratory symptoms ever (normal group), or reporting a diagnosisof asthma (asthma group), or reporting recurrent wheezing not diagnosed asasthma (wheeze group), or reporting exposure to industrial irritants, but not asthma or wheezing (exposed group). Current respiratory symptoms, airway responsiveness to methacholine challenge, and sputum cell counts were determined. The study was completed by 107 subjects aged 20 to 44 years. Results: There were no significant differences in FEV1 percent predicted, total cell count, and sputum eosinophil count among the four groups. Subjects with reported asthma had greater airway responsiveness as reflected in alower bronchial reactivity (BR) index. There was a weak correlation between BR index and sputum eosinophils. Conclusion: In a community setting, induced sputum eosinophil cell counts in subjects reporting asthma or wheezing were most often within the normal range and not sufficiently often abnormal to be useful in validating a diagnosis of asthma in epidemiologic studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/02/20 alle ore 17:58:01